58933-96-3

Upstream product

• 106-44-5 p-cresol 
• 6627-55-0 2-bromo-p-cresol 
• 4039-32-1 lithium hexamethyldisilazane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 1349842-54-1 C₁₀H₁₆O₂Si 
• 1349842-56-3 tert-butyl (1-methyl-4-oxo-3-(trimethylsilyl)cyclohexa-2,5-dien-1-yl) malonate 
• 262373-15-9 4-methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1256156-88-3 1-benzyl-6-methyl-1H-benzo[d][1,2,3]triazole 
• 1373397-29-5 1-benzyl-5-methyl-1H-benzo[d][1,2,3]triazole 
• 1607790-59-9 4-methyl-2-(trimethylsilyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 

Relevant academic research and scientific papers

Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent

Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).

Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization

Rapid development in the last decade has rendered chiral organoiodine(I/III) catalysis a reliable methodology in asymmetric catalysis. However, due to the severely limited numbers of effective organoiodine catalysts, many reactions still give low to modes

Continuous-flow synthesis of trimethylsilylphenyl perfluorosulfonate benzyne precursors

2-(Trimethylsilyl)phenyl perfluorosulfonated aryne precursors may now be accessed using flow chemistry, enabling the fast preparation of pure compounds with no requirement for low temperature lithiation or column chromatography. The process has been adapted to novel nonaflate precursors, utilizing the cheaper and more user-friendly nonaflyl fluoride reagent. The resultant nonaflates are shown to successfully participate in a range of aryne reaction classes.

Regioselective and stereoselective cyclizations of cyclohexadienones tethered to active methylene groups

The cyclization of 2,5-cyclohexadienones tethered to activated methylene groups was studied. The substitution around the cyclohexadienone ring serves to regioselectively direct these cyclizations based primarily on electronic effects. In the case of brominated substrates, these reactions proceed to give highly unusual electron-deficient tricyclic cyclopropanes. By using a Cinchona alkaloid-based phase-transfer catalyst, prochiral cyclohexadienones can be desymmetrized with moderate stereoselectivity.