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5896-07-1

6Abeta-aporphine-10,11-diol, hydrochloride (8ci) is a chemical compound belonging to the aporphine alkaloid class, characterized by its unique structure and properties. Aporphine alkaloids are a group of naturally occurring organic compounds derived from plants, known for their diverse range of biological activities, including anti-inflammatory, antitumor, and central nervous system effects. The specific compound, 6Abeta-aporphine-10,11-diol, hydrochloride, is a derivative of the aporphine core structure, with hydroxyl groups at the 10 and 11 positions and a hydrochloride salt form. 6Abeta-aporphine-10,11-diol, hydrochloride (8ci) has potential applications in pharmaceutical research and development, particularly in the exploration of its therapeutic properties and mechanisms of action.

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  • 5896-07-1 Structure

  • Basic information

    1. Product Name: 6Abeta-aporphine-10,11-diol, hydrochloride (8ci)
    2. Synonyms: 4H-Dibenzo(de,G)quinoline-10,11-diol, 5,6,6A,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6ar)-;5,6,6A,7-Tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid;6Abeta-aporphine-10,11-diol, hydrochloride (8ci);6A-beta-Noraporphine-10,11-diol, 6-methyl-, hydrochloride
    3. CAS NO:5896-07-1
    4. Molecular Formula: C17H18ClNO2
    5. Molecular Weight: 303.78332
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 5896-07-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6Abeta-aporphine-10,11-diol, hydrochloride (8ci)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6Abeta-aporphine-10,11-diol, hydrochloride (8ci)(5896-07-1)
    11. EPA Substance Registry System: 6Abeta-aporphine-10,11-diol, hydrochloride (8ci)(5896-07-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5896-07-1(Hazardous Substances Data)

5896-07-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5896-07-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,9 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5896-07:
(6*5)+(5*8)+(4*9)+(3*6)+(2*0)+(1*7)=131
131 % 10 = 1
So 5896-07-1 is a valid CAS Registry Number.

5896-07-1Relevant articles and documents

Convergent Total Synthesis of (±)-Apomorphine via Benzyne Chemistry: Insights into the Mechanisms Involved in the Key Step

Muraca, Ana Carolina A.,Perecim, Givago P.,Rodrigues, Alessandro,Raminelli, Cristiano

, p. 3546 - 3557 (2017)

Convergent total synthesis of (±)-apomorphine hydrochloride was accomplished by an approach that employs in the key step a sequence of transformations involving a [4+2]-cycloaddition reaction followed by a hydrogen migration. Through this sequence of transformations, the desired aporphine core was obtained regioselectively in 75% isolated yield. Since only one regioisomer was produced in the key step of the synthesis, a polar [4+2]-cycloaddition mechanism was proposed. Furthermore, NMR experiments and theoretical calculations were carried out to elucidate the hydrogen migration mechanism. (±)-Apomorphine hydrochloride was achieved after 9 steps in an overall yield of 8% involving benzyne chemistry.

PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES

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, (2021/02/12)

The present invention relates to pharmaceutical compositions for administration to mammals that include (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient that provides pharmacokinetic profiles useful for the treatment of neurodegenerative diseases.

PHARMACEUTICAL COMPOSITIONS OF (6AS)-6-METHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL

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, (2021/02/12)

This invention relates to pharmaceutical compositions for enhancing the solubility of (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol and salt forms thereof.

PRODUCTION PROCESS OF A HYDROCHLORIC ACID SALT OF APOMORPHINE AND DERIVATIVES THEREOF

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Page/Page column 14; 15; 16, (2021/05/07)

The present invention provides processes for the preparation of a hydrochloric acid salt of compound of formula (2): (I) Compound of formula (2) wherein: R1 is selected from the group consisting of -H, an unsubstiuted straight-chain C1-C20-alkyl, substituted straight-chain C1-C20-alkyl, unsubstituted branched -chain C1-C20-alkyl, substituted branched-chain C1-C20-alkyl, unsubstituted cyclic C3-C20-alkyl, and substituted cyclic C3-C20-alkyl; and R2 is selected from the group consisting of an unsubstituted straight-chain C1-C20-alkyl, substituted straight-chain C1-C20-alkyl, unsubstituted branched-chain C1-C20-alkyl, substituted branched-chain C1-C20-alkyl, unsubstituted cyclic C3-C20-alkyl, substituted cyclic C3-C20-alkyl, unsubstituted -C1-20-alkyl-C3-20-cycloalkyl, substituted -C1-20-alkyl-C3-20-cycloalkyl, unsubstituted allyl and substituted allyl.

FACILE 'ONE POT' PROCESS FOR APOMORPHINE FROM CODEINE

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Page/Page column 5, (2009/04/25)

An improved method for producing apomorphine and derivatives thereof is provided. The method is a convenient 'one-pot' process, comprising the conversion of codeine into apomorphine without isolating the apocodeine intermediate. Use of water reactive scavengers, reagents that will react irreversibly with water, decreases side product formation and allows the use of milder reaction conditions. This one-pot synthesis of apomorphine from codeine provides a faster reaction with improved yields at temperatures lower as compared to conventional methods. The lower operating temperatures and less volatile reactants make the method particularly useful for large-scale manufacturing.

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