58997-11-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Methylisonicotinic acid ethyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methylisonicotinic acid ethyl ester serves as an essential intermediate for the production of agrochemicals. Its role in the synthesis of active ingredients for pesticides and other agricultural chemicals helps improve crop protection and yield.
Used in Research and Development Laboratories:
3-Methylisonicotinic acid ethyl ester is employed as a crucial component in various chemical processes within research and development laboratories. Its versatility and reactivity make it an indispensable tool for scientists working on the discovery and optimization of new chemical entities.

InChI:InChI=1/C7H7NO2/c1-5-4-8-3-2-6(5)7(9)10/h2-4H,1H3,(H,9,10)

Upstream product

• 108-99-6 3-Methylpyridine 
• 541-41-3 chloroformic acid ethyl ester 
• 1681-36-3 4-chloro-3-methylpyridine 
• 7584-05-6 3-methyl-4-cyanopyridine 
• 583-58-4 3,4-Lutidin 
• 4021-12-9 3-methyl-isonicotinic acid 
• 64-17-5 ethanol 

Downstream Products

• 94015-27-7 2,5-dihydro-2-phenylpyrazolo<3',4':5,6>thiopyrano<3,4-c>pyridin-6-ium-3-olate 
• 38070-73-4 4-hydroxymethyl-3-methylpyridine 
• 479612-36-7 (2-chloro-5-methylpyridin-4-yl)methanol 
• 301666-87-5 3-Methyl-1-oxy-isonicotinic acid ethyl ester 
• 301666-68-2 ethyl 3-bromomethylpyridine-4-carboxylate 
• 58553-54-1 ethyl 3-chloromethylpyridine-4-carboxylate 
• 176178-87-3 3-methylisonicotinohydrazide 

Relevant academic research and scientific papers

QUINUCLIDINONE ANALOGUES AS ANTICANCER AGENTS

The disclosure includes compounds of Formula (I) and Formula(A) wherein R1, R2, R3, m, n, k, and L are defined herein. Also disclosed are methods for treating a neoplastic disease, autoimmune disease, or an inflammatory disorder with these compounds.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form -(CH2)m-, -N=CH-, -CH=N-, or -(C1-6 alkyl)C=N-; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group -C(=O)N(R5)R6 or group -C(=O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, -SO2-, -SO-, -CH2-CH2-, or - CH=CH-, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents - (CH2)n-, -O-(CH2)i-, or -C(=O)NH-(CH2)i-.

Preparation of some Thiopyranopyridine Derivatives

In the first systematic study of thiopyranopyridines in which the sulphur atom is separated from the pyridine ring by one carbon atom, the four isomeric enol esters, ethyl 5-hydroxy-8H-thiopyranopyridine-6-carboxylate (4b), ethyl 8-hydroxy-5H-thiopyranopyridine-7-carboxylate (5b), and ethyl 4-hydroxy-1H-thiopyrano- and pyridine-3-carboxylate (6b) and (7b), have been synthesised.Improved methods for the preparation of their pyridine precursors are described.With phenylhydrazine, the enol esters (4b) - (7b) give condensed pyrazole derivatives (15) - (18), which have dipolar structures; with hot mineral acid they undergo decarboxylative hydrolysis, to give the corresponding oxothiopyranopyridines (4a) - (7a).