590-88-5

Basic information

• Product Name: 1-methyltrimethylenediamine
• Synonyms: 1-methyltrimethylenediamine;1,3-Diaminobutane;1-Methyl-1,3-propanediamine;Butane-1,3-diamine;(3-amino-1-methyl-propyl)amine
• CAS NO: 590-88-5
• Molecular Formula: C₄H₁₂N₂
• Molecular Weight: 88.15148
• EINECS: 209-692-0
• Mol File: 590-88-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 1.63°C (estimate)
• Boiling Point: 113.17°C (rough estimate)
• Flash Point: 36.5°C
• Appearance: /
• Density: 0.8500
• Vapor Pressure: 6.69mmHg at 25°C
• Refractive Index: 1.4459 (estimate)
• PKA: 10.48±0.35(Predicted)
• CAS DataBase Reference: 1-methyltrimethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyltrimethylenediamine(590-88-5)
• EPA Substance Registry System: 1-methyltrimethylenediamine(590-88-5)

Safety Data

• RIDADR: 2733
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 590-88-5(Hazardous Substances Data)

Usage

Classification

Organic compound

Type of compound

Diamine

Functional groups

Primary amine, tertiary amine

Structure

Amino groups linked by a three-carbon chain

Usage

Curing agent for epoxy resins

Function in epoxy resins

Hardener, promoting cross-linking and enhancing mechanical properties

Other applications

Production of polyurethane foams, adhesives, stabilizer for organic peroxides, corrosion inhibitor

Hazard classification

Hazardous substance

Safety precautions

Wear protective equipment, follow proper safety protocols

InChI:InChI=1/C4H12N2/c1-4(6)2-3-5/h4H,2-3,5-6H2,1H3

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Downstream Products

• 878799-20-3 tert-butyl (3-aminobutyl)carbamate 

Relevant articles and documents

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.

Synthesis of tricyclic nitrogen heterocycles by a sequence of palladium-catalyzed N-H and C(sp3)-H arylations

A range of tricyclic nitrogen heterocycles were synthesized in a straightforward and efficient manner via a sequence involving palladium-catalyzed N-arylation and C(sp3)-H arylation as the key steps. Whereas the C(sp3)-H arylation furnished fused 6,5,6-membered ring systems efficiently, the formation of the more strained 6,5,5-membered systems proved to be more challenging and required a subtle adjustment of the reaction conditions.

KINETIC STUDY OF MECHANISM IN SCISSION OF 2-METHYLAZETIDINE BY NITROGEN-CONTAINING NUCLEOPHILES

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