59058-14-9Relevant academic research and scientific papers
Method for preparing alpha-acyloxy ketone compound
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Paragraph 0028, (2017/04/28)
The invention discloses a method for preparing an alpha-acyloxy ketone compound. According to the invention, simple and easily available alcohol and carboxylic acid are taken as the raw materials, under mediation of NBS(N-bromo-succinimide) and DBU(1,8-diazabicyclo(5.4.0)undec-7-alkene), the alpha-acyloxy ketone is prepared by a one-pot reaction. The method has the advantages of mild reaction condition, simple and easily available raw materials, wide substrate adaptation scope, no requirement of rigorous reaction conditions such as any metal catalyst, peroxy compounds, low or high temperature and water-free and oxygen-free conditions, metal pollution is avoided; and the method also has the advantages of stable technical condition, simple and safe operation, and easy purifying of the product.
NBS/DBU mediated one-pot synthesis of α-acyloxyketones from benzylic secondary alcohols and carboxylic acids
Zhu, Minghui,Wei, Wei,Yang, Daoshan,Cui, Hong,Cui, Huanhuan,Sun, Xuejun,Wang, Hua
supporting information, p. 10998 - 11001 (2016/12/06)
A simple and efficient one-pot NBS/DBU-mediated method has been developed for the synthesis of α-acyloxyketones from various benzylic secondary alcohols and carboxylic acids. Through this methodology, a series of α-acyloxyketones could be obtained in good to excellent yields under mild conditions. Importantly, this new reaction avoids the direct usage of toxic metal catalysts or potentially dangerous peroxide oxidants.
A rapid and facile esterification of na-carboxylates with alkyl halides promoted by the synergy of the combined use of DMSO and an ionic liquid under ambient conditions
Dighe, Satish N.,Bhattad, Ravindra V.,Kulkarni, Raghunath R.,Jain, Kishor S.,Srinivasan, Kumar V.
experimental part, p. 3522 - 3527 (2011/02/22)
The synergy of the combined use of DMSO and an ionic liquid viz. (bbim) has brought about a rapid and efficient esterification of sodium carboxylates with acyl and alkyl halides under ambient conditions in excellent isolated yields (90-95%) in short reaction times (12-40min). Copyright Taylor & Francis Group, LLC.
Organic reactions in water: Synthesis of phenacyl esters from phenacyl bromide and potassium salts of aromatic acids in the presence of β-cyclodextrin
Narender,Somi Reddy,Pavan Kumar,Rama Rao
, p. 1681 - 1686 (2007/10/03)
A convenient and facile synthesis of phenacyl esters is reported by the reaction of phenacyl bromide with potassium salts of aromatic acids in the presence of β-cyclodextrin in water under neutral conditions. Copyright Taylor & Francis, Inc.
Organic Reactions in Ionic Liquids: Ionic Liquid-Accelerated Nucleophilic Substitution Reaction of α-Tosyloxyketones with Potassium Salts of Aromatic Acids
Liu, Zhi,Chen, Zhen-Chu,Zheng, Qin-Guo
, p. 33 - 36 (2007/10/03)
The room temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) is used as a 'green' recyclable alternative to classical molecular solvents for the nucleophilic substitution reaction of α-tosyloxy ketones with pota
Kinetics of the Reactions of Phenacyl Bromide and of para-Substituted Phenacyl Bromides with Benzoate and Substituted trans-Cinnamate Ions
Srinavasan, Chockalingam,Shunmugasundaram, Arunachalam,Arumugam, Natesan
, p. 17 - 20 (2007/10/02)
The second-order rate constants for the reactions of various para-substituted phenacyl bromides with benzoate ion and with several substituted trans-cinnamate ions have been measured in 90 percent acetone - 10 percent water (v/v) mixture.Electron-releasin
Separation of Polar and Steric Effects in Reactions of ortho-Substituted Benzoate Ions with para-Substituted Phenacyl Bromides
Srinivasan, C.,Shunmugasundaram, A.,Roja, M.,Arumugam, N.
, p. 555 - 557 (2007/10/02)
The second order rate constants for SN2 reactions of several ortho-substituted benzoate ions with several para-substituted phenacyl bromides have been measured in 90percent acetone - 10percent water (v/v) mixture at 35 deg C.Satisfactory correl
