59083-36-2

Usage

Chemical class

piperidine, a class of organic compounds

Structure

piperidine backbone with a benzyl group and a phenyl group attached, and a methanol group attached to the piperidine ring

Psychoactive properties

acts as a stimulant of the central nervous system

Mechanism of action

vesicular monoamine transporter 2 (VMAT2) inhibitor, affecting the transportation of certain neurotransmitters in the brain

Potential therapeutic applications

treatment for Parkinson's disease and drug addiction

Potential risks

abuse as a recreational drug due to its psychoactive effects

InChI:InChI=1/C19H23NO/c21-16-19(18-9-5-2-6-10-18)11-13-20(14-12-19)15-17-7-3-1-4-8-17/h1-10,21H,11-16H2

Upstream product

• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 75930-61-9 1'-benzylspiro hydrochloride 
• 75930-63-1 1'-benzylspiro-1-one hydrochloride 
• 77607-28-4 1'-benzylspiro-1-one 

Relevant academic research and scientific papers

1-AZONIABICYCLO[2.2.1]HEPTANES, METHODS OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

The invention relates to quaternary basic amides of the formula STR1 in which Ar is an optionally substituted mono-, di-or tricyclic aromatic or heteroaromatic group;T is a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C 1-C. sub.4, or a C 1-C 5-alkylene group; Ar' is an unsubstituted or mono-or poly-substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl; R is hydrogen or a C 1-C. sub.4-alkyl, or a C 1-C 4-ω-alkoxy(C 2-C 4) alkyl, or a C 2-C 4-ω-alkanoyloxy (C 1-C 4)alkyl;.Q is hydrogen;or else Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group;Am ⊕ is the radical STR2 in which X 1, X 2 and X 3, together with the nitrogen atom to which they are bonded, form a 1-AZONIABICYCLO[2.2.1] HEPTANE optionally substituted by a phenyl or benzyl group; and A . crclbar. is a pharmaceutically acceptable anion. These compounds are useful for the preparation of drugs intended for the treatment of pathological conditions involving the tachykinin system.