59092-97-6Relevant academic research and scientific papers
BIOSYNTHESIS OF MANGIFERIN IN ANEMARRHENA ASPHODELOIDES BUNGE. II. C-GLUCOSYLATION OF MANGIFERIN
Fujita, Masao,Inoue, Takao
, p. 2482 - 2486 (2007/10/02)
A benzophenone, maclurin-1,3,5-14C3 (3), was efficiently incorporated into C-glucosylxanthones (mangiferin (1) and isomangiferin (2)) of Anemarrhena asphodeloides without randomization, but the labelled aglycone of 1 and 2 (1,3,6,7-tetrahydroxyxanthone-2,4,9a-14C3) (4) was essentially not incorporated.Furthermore, the incorporation of phenylalanine-3-14C into 1 and 2 was clearly suppressed by the addition of non-labelled maclurin (3) to the precursor solution.These results indicate that C-glucosylation of 1 and 2 occurs at the stage of maclurin (3), prior to the formation of the xanthone nucleus, and that 1 and 2 may be biosynthesized via 3-C-glucosylmaclurin (6).A biosynthetic route is proposed for mangiferin (1) and related C-glucosylxanthones.Keywords-Anemarrhena asphodeloides Bunge; biosynthesis; C-glucosylation of xanthone; mangiferin; isomangiferin; maclurin-1,3,5-14C3; 1,3,6,7-tetrahydroxyxanthone-2,4,9a-14C3; phloroglucinol-2,4,6-14C3.
