5981-37-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 2,5-dihydroxy-4-methoxy-, is used as a pharmaceutical compound for its potential therapeutic applications. Its antioxidant properties may help in the development of treatments for various diseases associated with oxidative stress, such as neurodegenerative disorders and cardiovascular diseases. Furthermore, its antimicrobial properties can be utilized in the formulation of drugs targeting bacterial infections.
Used in Food Industry as a Natural Preservative:
Benzoic acid, 2,5-dihydroxy-4-methoxy-, is used as a natural food preservative due to its antimicrobial properties. It can help extend the shelf life of food products by inhibiting the growth of spoilage-causing microorganisms, ensuring the safety and quality of the food. As a natural alternative to synthetic preservatives, it can be a preferred choice for consumers seeking healthier and more natural food options.
Used in Cosmetics Industry:
In the cosmetics industry, benzoic acid, 2,5-dihydroxy-4-methoxy-, can be used as an ingredient in skincare and personal care products. Its antioxidant properties may help protect the skin from oxidative stress and environmental damage, promoting skin health and reducing the signs of aging. Additionally, its antimicrobial properties can contribute to the formulation of products with antibacterial and anti-inflammatory effects.
Used in Agriculture:
Benzoic acid, 2,5-dihydroxy-4-methoxy-, can be utilized in agriculture as a natural pesticide or fungicide. Its antimicrobial properties can help protect crops from various diseases and pests, promoting healthy plant growth and increasing crop yields. As a natural alternative to synthetic pesticides, it can be an eco-friendly and sustainable solution for modern agriculture.

Upstream product

• 42189-58-2 2-Hydroxy-4-methoxy-5-methoxymethoxy-benzoic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 42189-57-1 1-(4-Methoxy-2,5-bis-methoxymethoxy-phenyl)-ethanone 
• 2237-36-7 4-methoxysalicylic acid 
• 645-08-9 Isovanillic acid 
• 22089-12-9 2,5-dihydroxy-4-methoxyacetophenone 

Downstream Products

• 38156-66-0 2-Carbomethoxy-5-methoxy-1,4-benzoquinone 
• 80902-77-8 methyl 2,4-dimethoxy-5-methoxycarbonyloxybenzoate 
• 3542-72-1 norathyriol 
• 20029-76-9 methyl 2,4,5-trimethoxybenzoate 
• 80902-76-7 2-hydroxy-4-methoxy-5-methoxycarbonyloxybenzoic acid 
• 13618-45-6 methyl 2,5-dihydroxy-4-methoxybenzoate 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 490-64-2 asaronic acid 
• 59092-97-6 1,3,7-trihydroxy-6-methoxyxanthone 
• 77800-61-4 5-ethoxy-2-hydroxy-4-methoxy-benzoic acid 

Relevant academic research and scientific papers

ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF

Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are represented by Formula I, while certain urolithin precursors are represented by Formula IV. The urolithin may be urolithin A, urolithin B, urolithin C, or urolithin D. The urolithin precursor may be ellagic acid or an ellagitannin. The methods include in vivo, ex vivo, and in vitro uses of the compounds and compositions.

Functional annotation and characterization of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1

The genome of Rhodococcus jostii RHA1 contains an unusually large number of oxygenase encoding genes. Many of these genes have yet an unknown function, implying that a notable part of the biochemical and catabolic biodiversity of this Gram-positive soil actinomycete is still elusive. Here we present a multiple sequence alignment and phylogenetic analysis of putative R. jostii RHA1 flavoprotein hydroxylases. Out of 18 candidate sequences, three hydroxylases are absent in other available Rhodococcus genomes. In addition, we report the biochemical characterization of 3-hydroxybenzoate 6-hydroxylase (3HB6H), a gentisate-producing enzyme originally mis-annotated as salicylate hydroxylase. R. jostii RHA1 3HB6H expressed in Escherichia coli is a homodimer with each 47 kDa subunit containing a non-covalently bound FAD cofactor. The enzyme has a pH optimum around pH 8.3 and prefers NADH as external electron donor. 3HB6H is active with a series of 3-hydroxybenzoate analogues, bearing substituents in ortho- or meta-position of the aromatic ring. Gentisate, the physiological product, is a non-substrate effector of 3HB6H. This compound is not hydroxylated but strongly stimulates the NADH oxidase activity of the enzyme.

Synthesis of mangiferin, isomangiferin, and homomangiferin

Mangiferin, isomangiferin, and homomangiferin, the xanthone C-glycosides with a wide spectrum of pharmacological effects, were synthesized concisely, featuring a C-glycosylation of a xanthene derivative with perbenzylglucopyranosyl N-phenyltrifluoroacetimidate.

Composition based on N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives

Compositions comprising, in a physiologically acceptable medium, N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives may be used for depigmenting and/or lightening the skin, the body hair, and/or the head hair by applying such a composition to the skin, the body hair, and/or the head hair.

Utilization of derivatives of 2,5-dihydroxyphenyl-carboxylic acids, their homologs, and their salts in preparation of a cosmetic or dermatological composition with a depigmenting action

A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: STR1 wherein: R1 re

Diels-Alder Approaches to Model Compounds Related to Fredericamycin A

A series of model compounds related to the antitumor and antibiotic compound fredericamycin A has been prepared.Spiro-2,5-dione (2) has been prepared and established as a novel spiro dienophile in the Diels-Alder reaction with 1,3-butadiene, Danishefsky's diene, a triacetoxy-substituted o-quinodimethane, and two isobenzofuran intermediates.Thus, the cycloaddition of 3-cyano-4,5,7-trimethoxy-1(3H)-isobenzofuranone (35) and 2 afforded 4,9-dihydroxy-5,6,8-trimethoxyspiroindene-2,1'-indan>-1,3-dione (38) in 62percent yield.This methodology provides a viable synthetic route to the quinone portion of fredericamycin A that contains the seven requisite oxygens.