5910-05-4

Basic information

• Product Name: Methyl 5-formylpyrrole-3-carboxylate
• Synonyms: Methyl 5-formylpyrrole-3-carboxylate
• CAS NO: 5910-05-4
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Mol File: 5910-05-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 367.6°C at 760 mmHg
• Flash Point: 176.1°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: Methyl 5-formylpyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-formylpyrrole-3-carboxylate(5910-05-4)
• EPA Substance Registry System: Methyl 5-formylpyrrole-3-carboxylate(5910-05-4)

Safety Data

• Hazardous Substances Data: 5910-05-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-2-6(4-9)8-3-5/h2-4,8H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 75866-92-1 N-((1H-pyrrol-2-yl)methylene)-N-methylmethanaminium hydrogen chloride 
• 76-02-8 trifluoroacetyl chloride 
• 66832-08-4 5-cyano-pyrrole-3-carboxylic acid methyl ester 
• 117720-03-3 2,7-Dibromo-N,N,N',N'-tetramethyl-5H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazine-5,10-diamine 
• 179928-10-0 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine 
• 67-56-1 methanol 
• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 155345-18-9 methyl 1-methoxymethyl-5-tosylmethyl-1H-pyrrole-3-carboxylate 
• 346669-60-1 5-[1-hydroxy-2-[4-(methoxycarbonyl)-1-(methoxymethyl)-1H-pyrrol-2-yl]-2-[(4-methylphenyl)sulfonyl]ethyl]-1-methyl-1H-pyrrole-3-carboxylic acid methyl ester 
• 346669-61-2 methyl 2-[2-(4-methoxycarbonyl-N-methyl-2-pyrrolyl)-2-oxo-1-tosyl]ethyl-N-methoxymethyl-4-pyrrolecarboxylate 
• 1144047-33-5 7-ethyl 2-methyl 6-methylindolizine-2,7-dicarboxylate 
• 482583-71-1 5-formyl-1-methylpyrrole-3-carboxylic acid 
• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 
• 198703-18-3 methyl 5-vinylpyrrole-3-carboxylate 

Relevant articles and documents

5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS

The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.

Oxidative Aza-Annulation of Enynyl Azides to 2-Keto/Formyl-1H-pyrroles

A method for the construction of pyrroles bearing a 2-keto or formyl group through the intramolecular oxidative aza-annulation of enynyl azides is reported for the first time. It involves a sequential carbon-nitrogen/carbon-oxygen bond formations, and the combination of AuCl3 with AgSbF6 was identified as a suitable reagent system to promote the present reaction. The required enynyl azides are readily prepared from Morita-Baylis-Hillman (MBH) acetates of acetylenic aldehydes.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein X1, X2, X3, R2, R4b, R1, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.