5910-56-5

Basic information

• Product Name: 3-[(2,2-DIMETHYLPROPANOYL)AMINO]PROPANOIC ACID
• Synonyms: N-(2,2-Dimethyl-1-oxopropyl)-beta-alanine
• CAS NO: 5910-56-5
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.21
• Mol File: 5910-56-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 131.0-132.5 °C
• Boiling Point: 375.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.074±0.06 g/cm3(Predicted)
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: 3-[(2,2-DIMETHYLPROPANOYL)AMINO]PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(2,2-DIMETHYLPROPANOYL)AMINO]PROPANOIC ACID(5910-56-5)
• EPA Substance Registry System: 3-[(2,2-DIMETHYLPROPANOYL)AMINO]PROPANOIC ACID(5910-56-5)

Safety Data

• Hazardous Substances Data: 5910-56-5(Hazardous Substances Data)

Upstream product

• 27019-47-2 β-alanine benzyl ester p-toluenesulfonate 
• 3282-30-2 pivaloyl chloride 
• 107-95-9 3-amino propanoic acid 
• 4138-35-6 methyl 3-aminopropanoate 
• 3196-73-4 methyl 3-aminopropanoate hydrochloride 

Relevant articles and documents

Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity

Antiallergic drug cyproheptadine (Cyp) is known to have inhibitory activities for L-type calcium channels in addition to histamine and serotonin receptors. Since we found that Cyp had an inhibitory activity against N-type calcium channel, Cyp was optimized to obtain more selective N-type calcium channel blocker with analgesic action. As a consequence of the optimization, we found 13 with potent N-type calcium channel inhibitory activity which had lower inhibitory activities against L-type calcium channel, histamine (H1), and serotonin (5-HT2A) receptors than those of Cyp. 13 showed an oral analgesic activity in rat formalin-induced pain model.

NOVEL DIARYLALKENE DERIVATIVES AND NOVEL DIARYLALKANE DERIVATIVES

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH=CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V--W represents C=C, etc., n represents 0 to 3, Y1 represents O etc., B represents--(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents--CO--, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group,--COR18a,--COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.