59105-50-9

Usage

Uses

Used in Pharmaceutical Research:
(5-Bromopyridin-3-yl)(phenyl)methanone is used as a building block for the synthesis of biologically active molecules, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of diverse chemical entities with potential medicinal properties.
Used in Chemical Research:
In the realm of chemical research, (5-Bromopyridin-3-yl)(phenyl)methanone serves as a valuable tool for studying chemical reactions and mechanisms. Its presence in various reaction systems can provide insights into the behavior of similar compounds and contribute to a deeper understanding of organic chemistry principles.
Used in Agrochemical Development:
(5-Bromopyridin-3-yl)(phenyl)methanone may also have potential applications in the development of new agrochemicals. Its structural features could be leveraged to create compounds with pesticidal or herbicidal properties, enhancing agricultural productivity and crop protection.
Used in Organic Chemistry:
As a compound of interest in organic chemistry, (5-Bromopyridin-3-yl)(phenyl)methanone is utilized in the synthesis of various organic compounds. Its versatility in forming different chemical entities makes it a valuable resource for researchers exploring the synthesis and properties of novel organic molecules.

Upstream product

• 39620-02-5 5-bromonicotinoyl chloride 
• 71-43-2 benzene 
• 591-51-5 phenyllithium 
• 183608-47-1 N-methyl-N-methoxy-5-bromopyridine-3-carboxamide 
• 100-58-3 phenylmagnesium bromide 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 625-92-3 3,5-dibromopyridine 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 233770-01-9 3-bromo-5-iodopyridine 
• 135364-97-5 tert-butyl benzoyl(tert-butoxycarbonyl)carbamate 

Downstream Products

• 423761-53-9 N-[(5-bromo-pyridin-3-yl)-phenyl-methyl]-formamide 

Relevant academic research and scientific papers

Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic controlvs.kinetic control ofN,N-Boc2-amides

A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N-methylamides) with functionalized Grignard reagents is reported. This protocol offers rapid entry to functionalized biaryl ketones after Mg/halide exchange with i-PrMgCl·LiCl under operationally-simple and practical reaction conditions. The scope of the method is highlighted in >40 examples, including bioactive compounds and pharmaceutical derivatives. Collectively, this transition-metal-free approach offers a major advantage over the recently established cross-coupling of amides by oxidative addition of N-C(O) bonds. Considering the utility of amide acylation reactions in modern synthesis, we expect that this method will be of broad interest.

Kinetically Controlled, Highly Chemoselective Acylation of Functionalized Grignard Reagents with Amides by N?C Cleavage

The direct transition-metal-free acylation of amides with functionalized Grignard reagents by highly chemoselective N?C cleavage under kinetic control has been accomplished. The method offers rapid and convergent access to functionalized biaryl ketones through transient tetrahedral intermediates. The direct access to functionalized Grignard reagents by in situ halogen–magnesium exchange promoted by the versatile turbo-Grignard reagent (iPrMgCl?LiCl) permits excellent substrate scope with respect to both the amide and Grignard coupling partners. These reactions enable facile, operationally simple and chemoselective access to tetrahedral intermediates from amides under significantly milder conditions than chelation-controlled intermediates. This novel direct two-component coupling sets the stage for using amides as acylating reagents in an alternative paradigm to the metal-chelated approach, acyl metals and Weinreb amides.

Pleuromutilin derivatives such, its pharmaceutical composition and synthetic method and use thereof

The present invention relates to a class of pleuromytilin compounds represented by the following general formula (I), pharmaceutically acceptable salts and preparation methods thereof, and compositions comprising the compound represented by the general fo

NOVEL AZALIDE AND AZALACTAM DERIVATIVES AND PROCESS FOR THE PRODUCTION OF THE SAME

A compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, which is useful for a prophylactic and/or therapeutic treatment of a microbial infectious disease. [R1 is hydrogen atom, or a linear C1-6 alkylcarbonyl group; R2 is hydrogen atom, or a C1-6 alkylcarbonyl group; R3 is hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkenyl group, a C2-6 alkenylcarbonyl group, a C2-6 alkynyl group, or an Ar-B- group (Ar represents an aryl group, or a heterocyclic group, and B is a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C2-6 alkenyl group, a C2-6 alkenylcarbonyl group, or a C2-6 alkynyl group); R5, R6, R7, and R8 represent hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or an Ar-B'- group (B' is a C1-6 alkyl group, a C2-6 alkenyl group, or a C2-6 alkynyl group); X is oxygen atom, or an -NR4- group (R4 is hydrogen atom, a C1-6 alkyl group, or a C1-6 alkyl group which may be substituted with an Ar group); and R4' is hydrogen atom, or a group represented by the aforementioned formula (a) (R3" and R4" represent hydrogen atom, or a linear or branched C1-6 alkylcarbonyl group)]

Pharmaceutical compositions and methods for use

The present invention relates to diazabicyclic compounds, preferably to N-aryl diazabicyclic compounds. Of particular interest are 2-pyridinyl diazabicyclic compounds, such as (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. Othe

Pharmaceutical compositions and methods for use

The present invention relates to diazabicyclic compounds, preferably to N-aryl diazabicyclic compounds. Of particular interest are 2-pyridyl diazabicyclic compounds, such as (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. Other