59146-02-0Relevant academic research and scientific papers
Method of preparing aryl-(1-phthalimido)-alkyl ketones
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, (2008/06/13)
Aryl-(1-phthalimido)-alkyl ketones of the general formula STR1 are prepared by reacting a suitable aromatic compound with STR2 at least one hydrogen atom on the aromatic nucleus in an inert solvent and in the presence of iron-(III)-chloride with an N-phth
Ferric Chloride-Catalyzed Acylation of Aromatic Compounds with N-Phthaloyl-α-amino Acyl Chlorides without Racemisation
Effenberger, Franz,Steegmueller, Dieter
, p. 117 - 124 (2007/10/02)
Reactive aromatic compounds are acylated without racemisation to aryl 1-phthalimidoalkyl ketones 4 in good yields with N-phthaloyl-α-amino acid chlorides in the presence of catalytic amounts (1 to 5 mol-percent) of FeCl3.This new method is especially useful for the synthesis of the pharmacologically interesting alkoxyaryl 1-phthalimidoalkyl ketones 6, 8, 10, and 11, which cannot be prepared in reasonable yields in the presence of other FC catalysts such as AlCl3 or SnCl4.
