59146-96-2

Basic information

• Product Name: 2,3-DIMETHYL-6-NITROANILINE
• Synonyms: 6-NITRO-2,3-XYLIDINE;2,3-DIMETHYL-6-NITROANILINE;TIMTEC-BB SBB006536;2,3-DIMETHYL-6-NITROANILINE 98%;2,3-Dimethyl-6-nitroaniline,97%;2,3-Dimethyl-6-nitroaniline,6-Nitro-2,3-xylidine;(2,3-Dimethyl-6-nitrophenyl)amine;6-Nitro-2,3-xylidine, 2-Amino-3,4-dimethylnitrobenzene, 3-Amino-4-nitro-o-xylene
• CAS NO: 59146-96-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 59146-96-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 117-120 °C(lit.)
• Boiling Point: 314.38°C (rough estimate)
• Flash Point: 156 °C
• Appearance: Dark yellow to orange-brown/Crystalline Powder
• Density: 1.220±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000129mmHg at 25°C
• Refractive Index: 1.6273 (estimate)
• PKA: -0.16±0.25(Predicted)
• CAS DataBase Reference: 2,3-DIMETHYL-6-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHYL-6-NITROANILINE(59146-96-2)
• EPA Substance Registry System: 2,3-DIMETHYL-6-NITROANILINE(59146-96-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 59146-96-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10N2O2/c1-5-3-4-7(10(11)12)8(9)6(5)2/h3-4H,9H2,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 87-59-2 2,3-Dimethylaniline 
• 134-98-5 N-(2,3-dimethylphenyl)acetamide 
• 138330-47-9 2,3-dimethyl-6-nitroacetanilide 
• 114166-32-4 2,3-dimethyl-4-nitroacetanilide 
• 526-75-0 2,3-Dimethylphenol 
• 67-56-1 methanol 
• 603-06-5 1,2-dimethyl-3,4-dinitrobenzene 
• 7664-41-7 ammonia 
• 6665-95-8 2,3-dimethyl-6-nitrophenol 

Downstream Products

• 138330-47-9 2,3-dimethyl-6-nitroacetanilide 
• 101421-62-9 2-bromo-3,4-dimethyl-1-nitrobenzene 
• 41927-01-9 3,4-dimethyl-o-phenylenediamine 
• 1128-19-4 2,3,4-trimethyl-1-nitrobenzene 
• 208403-94-5 5,6-Dimethyl-1,4-dihydro-quinoxaline-2,3-dione 
• 217196-44-6 3-bromo-4-nitrophthalic acid 
• 909135-23-5 2-iodo-3,4-dimethyl-1-nitrobenzene 
• 1643440-55-4 2,5-diiodo-3,4-dimethylaniline 
• 1643440-54-3 3,6-diiodo-4-nitro-o-xylene 
• 1643440-51-0 4-iodo-5,6-dimethyl-2-nitroaniline 

Relevant articles and documents

One-pot reaction as an efficient method for rigid molecular tweezers

(Equation Presented) Rigid molecular tweezers are compounds of increasing scientific interest. As the structural requirements for such compounds are highly specific, few types of these tweezers are thus far known. The preparation of examples of rigid larg

Zur Synthese sulfonierter Derivate von 2,3-Dimethylanilin und 3,4-Dimethylanilin

Baking the hydrogensulfate salt of 2,3-dimethylaniline (1) or of 3,4-dimethylaniline (2) led to 4-amino-2,3-dimethylbenzenesulfonic acid (4) and 2-amino-4,5-dimethylbenzenesulfonic acid (5), respectively (Scheme 1).The sulfonic acid 5 was also obtained by treatment of 2 with sulfuric acid or by reaction of 2 with amido-sulfuric acid. 3-Amino-4,5-dimethylbenzenesulfonic acid (3) and 5-amino-2,3-dimethylbenzenesulfonic acid (6) were prepared by sulfonation of 1,2-dimethyl-3-nitrobenzene (9) to 3,4-dimethyl-5-nitrobenzenesulfonic acid (11) and of 1,2-dimethyl-4-nitrobenzene (10) to 2,3-dimethyl-5-nitrobenzenesulfonic acid (12), respectively, with subsequent Bechamp reduction (Scheme 1).Preparations of 2-amino-3,4-dimethylbenzenesulfonic acid (7) and of 6-amino-2,3-dimethylbenzenesulfonic acid (8) were achieved by the sulfur dioxide treatment of the diazonium chlorides derived from 3,4-dimethyl-2-nitroaniline (24) and from 2,3-dimethyl-6-nitroaniline (31) to 3,4-dimethyl-2-nitrobenzenesulfonyl chloride (29) and 2,3-dimethyl-6-nitrobenzenesulfonyl chloride (32), respectively, followed by hydrolysis to 3,4-dimethyl-2-nitrobenzenesulfonic acid (30) and 2,3-dimethyl-6-nitrobenzenesulfonic acid (33), and final reduction (Scheme 3).Compound 7 was also synthesized by reaction of 4-chloro-2,3-dimethylaniline (23) with amidosulfuric acid to 2-amino-5-chloro-3,4-dimethylbenzenesulfonic acid (20) and subsequent hydrogenolysis (Scheme 2). 4'-Bromo-2',3'-dimethyl-acetanilide (13) and 4'-chloro-2',3'-dimethyl-acetanilide (14) on treatment with oleum yielded 5-acetylamino-2-bromo-3,4-dimethylbenzenesulfonic acid (17) and 5-acetylamino-2-chloro-3,4-dimethylbenzenesulfonic acid (18), respectively.Their structures were proven by hydrolysis to 5-amino-2-bromo-3,4-dimethylbenzenesulfonic acid (21) and 5-amino-2-chloro-3,4-dimethylbenzenesulfonic acid (22), followed by reductive dehalogenation to 3.Reaction of 1 with sulfuric acid gave a mixture of 3,4 and 7, whereas sulfonation of 2',3'-dimethyl-acetanilide with subsequent hydrolysis led to a mixture of 3 and 4.Treatment of 3',4'-dimethyl-acetanilide with oleum followed by hydrolysis resulted in the formation of mainly 5 and a small amount of unknown product.