59184-53-1Relevant articles and documents
6H-indolo[2,3-b]quinoxaline derivative, and preparation method and application thereof
-
Paragraph 0049; 0050; 0051, (2019/12/25)
The invention provides a 6H-indolo[2,3-b]quinoxaline derivative, and a preparation method and application thereof. The general formula is as shown in the specification. The preparation method comprises a step of preparing the 6H-indolo[2,3-b]quinoxaline derivative by taking o-phenylenediamine, indoldione, dihaloalkane and amine compounds as raw materials. The compounds provided by the invention show good antitumor activity.
Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines
Shibinskaya, Marina O.,Lyakhov, Sergey A.,Mazepa, Alexander V.,Andronati, Sergey A.,Turov, Alexander V.,Zholobak, Nadezhda M.,Spivak, Nikolay Ya.
experimental part, p. 1237 - 1243 (2010/05/02)
New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. It was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series.
