59187-55-2

Upstream product

• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 610-14-0 2-nitrobenzyl chloride 
• 635-21-2 5-chloroanthranilic acid 
• 63243-75-4 ethyl 2-amino-5-chlorobenzoate 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 1352126-78-3 2-[2-(2-fluorobenzoylamino)benzoylamino]-5-chlorobenzoic acid 
• 33591-91-2 2-Hydroxymethyl-4-chlor-2'-aminobenzanilid 

Relevant academic research and scientific papers

Quinazolinone derivatives and production method and application thereof

The invention discloses quinazolinone derivatives and a production method and application thereof. The quinazolinone derivatives are synthesized by means of the simple and convenient method, the yields are high, the production cost is low, with a concentr

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

2-[2-Benzoylamino)benzoylamino]benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.