59211-00-6 Usage
Chemical class
Nucleoside analog
Explanation
A modified form of a natural nucleoside found in DNA and RNA.
Explanation
A sugar molecule that forms part of the compound's structure.
Explanation
A pyrimidine base that forms part of the compound's structure.
Explanation
A functional group that contributes to the compound's antiviral and anticancer properties.
Explanation
A functional group that contributes to the compound's antiviral and anticancer properties.
Explanation
The compound has the potential to interfere with the process of viral replication, making it a potential antiviral agent.
Explanation
The compound has the potential to limit the growth of cancer cells, making it a potential anticancer agent.
Explanation
Due to its antiviral and anticancer properties, the compound is a promising candidate for further research and development in the field of pharmaceuticals.
Sugar component
Pentofuranosyl
Base component
5-methylpyrimidine-2,4(1H,3H)-dione
Acetyl group
3-O-acetyl
Methylsulfonyl group
5-O-(methylsulfonyl)
Antiviral potential
Disruption of viral replication
Anticancer potential
Restriction of cancer cell growth
Pharmaceutical research
Promising candidate for further development
Check Digit Verification of cas no
The CAS Registry Mumber 59211-00-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,1 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59211-00:
(7*5)+(6*9)+(5*2)+(4*1)+(3*1)+(2*0)+(1*0)=106
106 % 10 = 6
So 59211-00-6 is a valid CAS Registry Number.
59211-00-6Relevant academic research and scientific papers
5'-S-NUCLEOSIDE TRIPHOSPHATES. SYNTHESIS AND SUBSTRATE PROPERTIES IN TESTS WITH DNA POLYMERASES
Shirokova, E. A.,Shipitsyn, A. V.,Kuznetsova, E. V.,Viktorova, L. S.,Kraevskii, A. A.
, p. 736 - 741 (2007/10/02)
With the aim of studying the properties of DNA polymerases in the biosynthesis of DNA we have synthesized the 5'-S-triphosphates of 5'-mercapto-5'-deoxythymidine and of 5'-mercapto-3',5'-dideoxythymidine from 3'-O-acetylthymidine and 3'-deoxythymidine, respectively.A study in cell-free systems with DNA polymerases of the triphosphate compounds obtained showed that 5'-mercapto-5'-deoxythymidine 5'-S-triphosphate possessed weak substrate properties, being included only once in the 3'-end of a growing DNA chain when the process was catalyzed by DNA polymerase I and AMV reverse transcriptase.At the same time, neither DNA polymerase α from human placenta, nor DNA polymerase β from rat liver, nor HIV reverse transcriptase interacted with these compounds at all. 5'-Mercapto-3',5'-dideoxythymidine 5'-triphosphate did not extend a DNA chain on catalysts by any of the above-mentioned enzymes.Possible reason for the sharp fall in the substrate properties of the compounds synthesized as compared with the natural substrates of DNA polymerases are discussed.
