59245-36-2

Basic information

• Product Name: 5-Deoxy-L-arabinose phenylhydrazone
• Synonyms: 5-Deoxy-L-arabinose phenylhydrazone
• CAS NO: 59245-36-2
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.25634
• Mol File: 59245-36-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Deoxy-L-arabinose phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Deoxy-L-arabinose phenylhydrazone(59245-36-2)
• EPA Substance Registry System: 5-Deoxy-L-arabinose phenylhydrazone(59245-36-2)

Safety Data

• Hazardous Substances Data: 59245-36-2(Hazardous Substances Data)

Upstream product

• 13039-56-0 5-deoxy-L-arabinose 
• 100-63-0 phenylhydrazine 
• 13039-80-0 5-deoxy-L-(+)-arabinose-diethylmercaptal 
• 5328-37-0 L-arabinose 
• 13039-79-7 5-tosyl-L-(+)-arabinose-diethylmercaptal 
• 43179-48-2 L-arabinose di(ethylthio)acetal 
• 54253-49-5 1,1-diethylsulfonyl-L-rhamnose 

Downstream Products

• 62933-57-7 1',2'-O-diacetyl-L-biopterin 
• 94591-31-8 2-N-Benzoyl-1',2'-di-O-benzoyl-4-thiobiopterin 
• 94591-29-4 2-N-Benzoyl-1',2'-di-O-benzoylbiopterin 
• 22150-76-1 biopterin 
• 95895-36-6 5-deoxy-2,3,4-O-triacetyl-L-arabinose-phenylhydrazone 
• 2236-60-4 pterin 
• 94591-24-9 Biolumazin 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISEASES

The invention relates to the compounds of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II or formula III; and methods for treating or preventing metabolic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of phenylketonuria, cardiovascular disease, autism, ADHD, hypertension, endothelial dysfunction and chronic kidney disease.

Crystalline polymorph of biopterin and production method thereof

Crystalline solids A to E of biopterin are distinguished from each other by diffraction angle in an X-ray powder diffraction pattern measured using Cu—Kα radiation. The crystalline solid A is characterized by strong peak at 4.6° and peaks at 13.6°, 18.1° and 27.5°; the crystalline solid B is characterized by strong peak at 4.85° and peaks at 2.4°, 13.2°, 18.1° and 27.3°; the crystalline solid C is characterized by strong peak at 5.35° and peaks at 10.8°, 21.9° and 27.3°; the crystalline solid D is characterized by strong peak at 5.1° and peaks at 2.6°, 9.2°, 13.4°, 15.4°, 18.3°, 21.8° and 27.3°; and the crystalline solid E is characterized by strong peaks at 4.5° and 5.8°, and peaks at 10.6°, 15.6°, 20.0°, 20.7°, 23.8° and 27.3°.

Method for producing L-biopterin

To provide a method for producing L-biopterin on a large industrial scale by using a reagent which is inexpensive and easy to handle, without requiring a use of any particular equipment or plants.

Process for preparing 5-deoxy-L-arabinose

The process for preparing 5-deoxy-arabinose comprises reacting 5-tosyl-L-arabinose-dialkylmercaptal with NaBH4 in DMSO to give 5-deoxy-L-arabinose-dialkylmercaptal and then reacting the obtained 5-deoxy-L-arabinose-dialkylmercaptal with hydrochloric acid in DMSO. According to the process, 5-deoxy-L-arabinose can be obtained in a high yield without employing heavy metal such as mercury.

169. Pterinechemistry Part 84 A New, Regiospecific Synthesis of L-Biopterin

Pure L-biopterin was obtained in 42percent yield by the condensation of 5-deoxy-L-arabinose-phenylhydrazone-triacetate with 4-hydroxy-2,5,6-triaminopyrimidine, followed by iodine oxidation of the formed tetrahydropterin derivative to 1',2'-O-diacetyl-L-biopterin.Deacetylation was carried out with NH4OH.

Pteridines, LXXV. - Synthesis and Properties of Biopterin and Biopterin Analogs

The synthesis of biopterin (6), its 2-N,N-dimethyl- (8) and 4-thioxo derivative (19) as well as biolumazine (7) is described.The side chain of biopterin can be modified by reaction of α-acetoxy-isobutyryl chloride to yield 6-(L-threo-2-acetoxy-1-chloropropyl)pterin (10), which can be used as a starting material for further derivatisations. 2,1',2'-Triacylbiopterins (14, 16) possess a hydrolytically labile N-acyl group.The newly synthesized compounds were characterized by pK-determinations, UV, and NMR spectra.