59247-48-2

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 67-63-0 isopropyl alcohol 
• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 201230-82-2 carbon monoxide 
• 106-40-1 4-bromo-aniline 
• 873-75-6 4-bromobenzenemethanol 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 1122-91-4 4-bromo-benzaldehyde 
• 939-48-0 isopropyl benzoate 
• 1428726-77-5 propan-2-yl 4-[(4-carbamoyl-1H-pyrazol-3-yl)amino]benzoate 
• 345964-81-0 1-bromo-4-(1-isopropoxyvinyl)-benzene 
• 916235-77-3 2,2'-bis(isopropoxycarbonyl)-3,3'-bis(3,5-diphenylphenyl)-5,5'-diphenyl-biphenyl 
• 475295-11-5 2,2'-bis(bromomethyl)-3,3'-bis(3,5-diphenylphenyl)-5,5'-diphenyl-biphenyl 
• 916235-72-8 3,4,5,3''',4''',5'''-hexafluoro-[1,1';3',3'';1'',1''']quaterphenyl-4',4''-dicarboxylic acid diisopropyl ester 
• 916235-75-1 4',4''-bis-bromomethyl-3,4,5,3''',4''',5'''-hexafluoro-[1,1';3',3'';1'',1''']quaterphenyl 
• 916235-76-2 3,3'-dibromo-2,2'-bis(isopropoxycarbonyl)-5,5'-diphenyl-biphenyl 
• 916235-70-6 2,2'-bis(isopropoxycarbonyl)-5,5'-diphenyl-biphenyl 
• 916235-73-9 2,2'-bis(bromomethyl)-5,5'-diphenyl-biphenyl 

Relevant academic research and scientific papers

Selective Oxidative Esterification from Two Different Alcohols via Photoredox Catalysis

Esters functionalities are important building blocks that are extensively used in the chemical industry and academic laboratories. Direct oxidative esterification from easy-available alcohols to esters would be a much more appealing approach, especially using O2as terminal oxidant. Inputting external energy by photocatalysis for dioxygen activation, a mild and simple method for ester synthesis from two different alcohols has been achieved in this work. This reaction is performed under neutral conditions using O2as the terminal oxidant. A variety of primary alcohols, especially long chain alcohols and secondary alcohols are tolerated in this system.

Metal-free radical aromatic carbonylations mediated by weak bases

We report a new method of metal-free alkoxycarbonylation. This reaction involves the generation of aryl radicals from arenediazonium salts by a very weak base (HCO2Na) under mild conditions. Subsequent radical trapping with carbon monoxide and alcohols gives alkyl benzoates. The conditions (metal-free, 1 equiv. base, MeCN, r.t., 3 h) tolerate various functional groups (I, Br, Cl, CF3, SF5, NO2, ester). Mechanistic studies indicate the operation of a radical aromatic substitution mechanism.

Metal-free carbonylations by photoredox catalysis

The synthesis of benzoates from aryl electrophiles and carbon monoxide is a prime example of a transition-metalcatalyzed carbonylation reaction which is widely applied in research and industrial processes. Such reactions proceed in the presence of Pd or Ni catalysts, suitable ligands, and stoichiometric bases. We have developed an alternative procedure that is free of any metal, ligand, and base. The method involves a redox reaction driven by visible light and catalyzed by eosin Y which affords alkyl benzoates from arene diazonium salts, carbon monoxide, and alcohols under mild conditions. Tertiary esters can also be prepared in high yields. DFT calculations and radical trapping experiments support a catalytic photoredox pathway without the requirement for sacrificial redox partners.

Asymmetric phase-transfer catalysis of homo- and heterochiral quaternary ammonium salts: development and application of conformationally flexible chiral phase-transfer catalysts

Inspired by the considerable difference of catalytic activity and stereocontrolling ability between the conformationally rigid, homo- and heterochiral quaternary ammonium bromides 1, conformationally flexible, N-spiro chiral quaternary ammonium bromides o

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI

Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.