59263-76-2 Usage
Description
Meptazinol hydrochloride is an injectable narcotic analgesic with antagonist
properties; it is similar in potency to meperidine. Meptazinol appears to have a
low propensity toward respiratory depression and other opiate-like side effects,
possibly due to selective interaction with the mu-1 receptor. Also somewhat
unique for an analgesic, it interacts with central cholinergic receptors. An oral
form of meptazinol is under development.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 59263-76-2 differently. You can refer to the following data:
1. Analgesic;Opiate receptor agonist
2. Mixed opioid agonist-antagonist. Analgesic (narcotic)
Brand name
MEPTID
Biological Activity
Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase.
Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 59263-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,6 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 59263-76:
(7*5)+(6*9)+(5*2)+(4*6)+(3*3)+(2*7)+(1*6)=152
152 % 10 = 2
So 59263-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H
