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| CAS No.: | 59263-76-2 |
|---|---|
| Name: | Meptazinol hydrochloride |
| Molecular Structure: | |
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| Formula: | C15H23NO.HCl |
| Molecular Weight: | 269.815 |
| Synonyms: | Phenol,3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride (9CI);IL 22811HCl;Meptamizol hydrochloride;Meptazinol hydrochloride;Meptid;Wy 22811;Wy22811 HCl; |
| EINECS: | 261-683-0 |
| Melting Point: | 250-252 °C |
| Boiling Point: | 354.8 °C at 760 mmHg |
| Flash Point: | 160.6 °C |
| Appearance: | White solid |
| Hazard Symbols: | Xn |
| Risk Codes: | 22 |
| PSA: | 23.47000 |
| LogP: | 3.89560 |
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Chemistry
Molecular Structure:
Molecular Formula: C15H24ClNO
Molecular Weight: 269.8102
IUPAC Name: 3-(3-Ethyl-1-methylazepan-3-yl)phenol hydrochloride
Synonyms of Meptazinol hydrochloride (CAS NO.59263-76-2): Meptazinol hydrochloride [USAN] ; 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride ; EINECS 261-683-0 ; IL 22811 ; Meptazinol HCl ; Phenol, m-(3-ethyl-1-methyl-hexahydro-1H-azepin-3-yl)-, hydrochloride ; WY 22811 ; m-(3-Ethyl-1-methyl-hexahydro-1H-azepin-3-yl)phenol hydrochloride ; m-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride ; Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride
CAS NO: 59263-76-2
Product Categories: Analgesic ; Drug / Therapeutic Agent
Melting point: 250-252°C
Flash Point: 160.6 °C
Enthalpy of Vaporization: 62.35 kJ/mol
Boiling Point: 354.8 °C at 760 mmHg
Vapour Pressure of Meptazinol hydrochloride (CAS NO.59263-76-2): 1.6E-05 mmHg at 25°C
Uses
Meptazinol hydrochloride (CAS NO.59263-76-2) is used as centrally active opioid analgesic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 118mg/kg (118mg/kg) | General Pharmacology. Vol. 9, Pg. 73, 1978. | |
| mouse | LD50 | oral | 282mg/kg (282mg/kg) | General Pharmacology. Vol. 9, Pg. 73, 1978. | |
| rat | LD50 | intraperitoneal | 106mg/kg (106mg/kg) | General Pharmacology. Vol. 9, Pg. 73, 1978. | |
| rat | LD50 | oral | 1260mg/kg (1260mg/kg) | General Pharmacology. Vol. 9, Pg. 73, 1978. |
Safety Profile
Specification
Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s. Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth).
Meptazinol is a 3-phenylazpane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes.
A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.