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59263-76-2

Basic Information
CAS No.: 59263-76-2
Name: Meptazinol hydrochloride
Article Data: 1
Molecular Structure:
Molecular Structure of 59263-76-2 (Meptazinol hydrochloride)
Formula: C15H23NO.HCl
Molecular Weight: 269.815
Synonyms: Phenol,3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride (9CI);IL 22811HCl;Meptamizol hydrochloride;Meptazinol hydrochloride;Meptid;Wy 22811;Wy22811 HCl;
EINECS: 261-683-0
Melting Point: 250-252 °C
Boiling Point: 354.8 °C at 760 mmHg
Flash Point: 160.6 °C
Appearance: White solid
Hazard Symbols: Xn
Risk Codes: 22
PSA: 23.47000
LogP: 3.89560
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Chemistry

Molecular Structure:

Molecular Formula: C15H24ClNO
Molecular Weight: 269.8102
IUPAC Name: 3-(3-Ethyl-1-methylazepan-3-yl)phenol hydrochloride
Synonyms of Meptazinol hydrochloride (CAS NO.59263-76-2): Meptazinol hydrochloride [USAN] ; 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride ; EINECS 261-683-0 ; IL 22811 ; Meptazinol HCl ; Phenol, m-(3-ethyl-1-methyl-hexahydro-1H-azepin-3-yl)-, hydrochloride ; WY 22811 ; m-(3-Ethyl-1-methyl-hexahydro-1H-azepin-3-yl)phenol hydrochloride ; m-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride ; Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride
CAS NO: 59263-76-2
Product Categories: Analgesic ; Drug / Therapeutic Agent
Melting point: 250-252°C 
Flash Point: 160.6 °C
Enthalpy of Vaporization: 62.35 kJ/mol
Boiling Point: 354.8 °C at 760 mmHg
Vapour Pressure of Meptazinol hydrochloride (CAS NO.59263-76-2): 1.6E-05 mmHg at 25°C

Uses

  Meptazinol hydrochloride (CAS NO.59263-76-2) is used as centrally active opioid analgesic.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 118mg/kg (118mg/kg)   General Pharmacology. Vol. 9, Pg. 73, 1978.
mouse LD50 oral 282mg/kg (282mg/kg)   General Pharmacology. Vol. 9, Pg. 73, 1978.
rat LD50 intraperitoneal 106mg/kg (106mg/kg)   General Pharmacology. Vol. 9, Pg. 73, 1978.
rat LD50 oral 1260mg/kg (1260mg/kg)   General Pharmacology. Vol. 9, Pg. 73, 1978.

Safety Profile

 

Safety Info
Symbol:
GHS07
Sign: Warning
hazard declaration: H302
hazard declaration add:  
waring notice:  
HS Code: 2942000000

Specification

 Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s. Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth).
Meptazinol is a 3-phenylazpane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes.
A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.