140464-70-6Relevant articles and documents
Asymmetric synthesis of a fully protected ent-actinoidinic acid
Wilhelm, Rene,Widdowson, David A.
, p. 3079 - 3082 (2001)
(equation presented) The asymmetric synthesis of a fully protected ent-actinoidinic acid derivative 14 is described. As key steps, an enantioselective deprotonation of an arenetricarbonylchromium(0) complex and a diastereoselective Suzuki coupling were ap
Protection and deprotection of acetals by using MoO3/SiO 2
Bhosale, Rajesh S.,Bhosale, Sidhanath V.,Bhosale, Sheshanath V.,Solanke, Kuldeep S.,Pawar, Rajendra P.,Chougule, Harish S.,Dongare, Mohan K.
, p. 659 - 663 (2007/10/03)
Acetalization of aldehydes using a new silica-supported molybdenum(VI) oxide (20%) catalyst has been explored. Additionally, facile deprotection strategy for the acetals is reported including the results from the replacement of solvent studies. The protocol achieved the protection O,O-acetals in excellent yield within a few hours under neutral conditions and also deprotection of aromatic O,O-acetals in excellent yields was achieved within a few minutes in aqueous acetone. Copyright Taylor & Francis Group, LLC.
3-AMINO-PYRAZOLO[3,4B]PYRIDINES USED AS INHIBITORS OF PROTEIN TYROSINE KINASES FOR TREATING ANGIOGENIC, HYPERPROLIFERATIVE OR NEURODEGENERATIVE DISEASES
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Page/Page column 72, (2008/06/13)
The invention relates to compounds of general formula (I), in which R1 and R2 are described in the application, to the use of the compounds of general formula (I) as inhibitors of protein tyrosine kinases for treating various diseases, and to the compounds of general formulas (II) and (III) as intermediate compounds for producing compounds of general formula (I), in which X, R1a and R2a have the meanings as described in general formulas (II) and (III).
Regioselective Reductive Electrophilic Substitution of Derivatives of 3,4,5-Trimethoxybenzaldehyde
Azzena, Ugo,Melloni, Giovanni,Piroddi, Anna Maria,Azara, Emanuela,Contini, Stefania,Fenude, Emma
, p. 3101 - 3106 (2007/10/02)
The behavior of several protected derivatives of 3,4,5-trimethoxybenzaldehyde has been investigated under conditions of electron transfer from alkali metals in aprotic solvents.The 4-methoxy group can be regioselectively removed in good to high yield under such conditions, and an appropriate choice of the protecting group, metal, and solvent allows its substitution with a variety of electrophiles. 3,4,5-Trimethoxybenzaldehyde dimethyl acetal, 1, is the starting material of choice for a new general synthetic approach to several polysubstituted resorcinol dimethyl ethers.Investigation of the mechanism of demethoxymetylation, with the aid of labeling experiments, showed that reductive demethoxylation is strongly influenced by the nature of the aldehyde protective group employed.