59277-99-5 Usage
General Description
2-[(2,6-dichloro-9H-purin-9-yl)methoxy]ethyl acetate is a chemical compound with the molecular formula C12H13Cl2N5O4. It is a derivative of the purine nucleoside adenosine and is commonly used as a building block for the synthesis of nucleoside analogs for antiviral and antitumor drugs. The compound is known for its potent antiviral activity and has been studied for its potential use in treating viral infections, including herpes and hepatitis B. It acts by inhibiting the replication of viral DNA and RNA, making it a promising candidate for the development of new antiviral medications. Additionally, the compound has shown potential as a cytotoxic agent in the treatment of certain types of cancer. Overall, 2-[(2,6-dichloro-9H-purin-9-yl)methoxy]ethyl acetate is a versatile and important chemical compound with a wide range of potential pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 59277-99-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,7 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 59277-99:
(7*5)+(6*9)+(5*2)+(4*7)+(3*7)+(2*9)+(1*9)=175
175 % 10 = 5
So 59277-99-5 is a valid CAS Registry Number.
59277-99-5Relevant articles and documents
Efficient synthesis of α-branched purine-based acyclic nucleosides: Scopes and limitations of the method
Dra?ínsky, Martin,Frydrych, Jan,Janeba, Zlatko,Slavětínská, Lenka Po?tová
, (2020/10/02)
An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employs cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction is carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibits a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.
Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[(2-hydroxyethoxy)methyl] heterocycles as 'acyclic nucleoside' analogues
Robins,Hatfield
, p. 547 - 553 (2007/10/02)
-
