59303-13-8

Basic information

• Product Name: 2-Methyl-5-propionylthiophene
• Synonyms: 1-(5-methyl-2-thienyl)propan-1-one(SALTDATA: FREE);1-(5-methyl-2-thienyl)propan-1-one;1-Propanone, 1-(5-methyl-2-thienyl)-;IVK/9079151
• CAS NO: 59303-13-8
• Molecular Formula: C₈H₁₀OS
• Molecular Weight: 154.23
• Product Categories: Thiophens
• Mol File: 59303-13-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 251.1 °C at 760 mmHg
• Flash Point: 105.7 °C
• Appearance: /
• Density: 1.076 g/cm³
• Vapor Pressure: 0.0208mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 2-Methyl-5-propionylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5-propionylthiophene(59303-13-8)
• EPA Substance Registry System: 2-Methyl-5-propionylthiophene(59303-13-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 59303-13-8(Hazardous Substances Data)

Usage

General Description

2-Methyl-5-propionylthiophene is a chemical compound with the molecular formula C8H10OS. It is a thiophene derivative with a methyl and propionyl group attached to the 2 and 5 positions, respectively. 2-Methyl-5-propionylthiophene is commonly used as a flavoring and fragrance agent in the food and beverage industry, providing a sweet, fruity, and burnt odor and taste. It is also used in the production of perfumes and may have potential applications in pharmaceuticals and agrochemicals due to its unique aromatic properties. However, it is important to handle this chemical with care as it may be hazardous if not used properly.

InChI:InChI=1/C8H10OS/c1-3-7(9)8-5-4-6(2)10-8/h4-5H,3H2,1-2H3

Upstream product

• 554-14-3 2-Methylthiophene 
• 79-03-8 propionyl chloride 
• 104863-65-2 N-methyl-N-methoxypropionamide 

Downstream Products

• 579-41-9 4,4,4-trifluoro-2-methyl-1-(5-methyl-[2]thienyl)-butane-1,3-dione 
• 1918-79-2 2-methylthiophene-5-carboxylic acid 
• 74047-61-3 2-methyl-1-(5-methylthiophen-2-yl)prop-2-en-1-one 
• 74047-60-2 4,5-dihydro-2,5-dimethyl-6H-cyclopentathiophen-6-one 

Relevant articles and documents

Structurally uniform 1-hexene, 1-octene, and 1-decene oligomers: Zirconocene/MAO-catalyzed preparation, characterization, and prospects of their use as low-viscosity low-temperature oil base stocks

An original approach to α-olefin oligomerization as well as novel thermally stable zirconocene catalysts for use in such reactions has been elaborated. The method reported allows the achievement of fractions of lightweight α-olefin oligomers up to 90% yields without considerable formation of byproducts like internal alkenes, alkanes, and higher oligomers. Trimers, tetramers, and pentamers of 1-hexene, 1-octene, and 1-decene were isolated as individual compounds and were hydrogenated. Viscosity characteristics of the isolated saturated and unsaturated hydrocarbons have been studied at various temperatures. The isolated saturated oligomers of 1-octene and 1-decene outperform the traditional electrophilic oligomerization products in terms of viscosity indexes, pour points, and low-temperature viscosity.

A chemoselective α-aminoxylation of aryl ketones: a cross dehydrogenative coupling reaction catalysed by Bu4NI

Tetrabutyl ammonium iodide (TBAI) catalyzed α-aminoxylation of ketones using aq. TBHP as an oxidant has been accomplished. We have shown that the CDC (cross dehydrogenative coupling) reactions of ketones with N-hydroxyimidates such as N-hydroxysuccinimide (NHSI), N-hydroxyphthalimide (NHPI), N-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) lead to the corresponding oxygenated products in good to moderate yields. The application of this method has been demonstrated by transforming a few coupled products into synthetically useful intermediates and products.