104863-65-2

Usage

Uses

Used in Industrial Applications:
N-Methoxy-N-methyl-propionamide is used as a solvent for its ability to dissolve a wide range of substances due to its high boiling point and low volatility.
Used in Pharmaceutical Production:
In the pharmaceutical industry, N-Methoxy-N-methyl-propionamide is utilized as an intermediate in the synthesis of various drugs, playing a crucial role in the development of new medications.
Used in Agrochemical Synthesis:
Similarly, in agrochemical production, N-METHOXY-N-METHYL-PROPIONAMIDE acts as an intermediate, contributing to the creation of substances designed to enhance crop protection and yield.
Used in Organic Synthesis:
N-Methoxy-N-methyl-propionamide is employed in organic synthesis, where it aids in the formation of complex organic molecules, showcasing its reactivity and functional group compatibility.
Used as a Chemical Reaction Stabilizer:
N-METHOXY-N-METHYL-PROPIONAMIDE also serves as a stabilizer in certain chemical reactions, helping to control reaction rates and improve the yield of desired products.

InChI:InChI=1/C5H11NO2/c1-4-5(7)6(2)8-3/h4H2,1-3H3

Upstream product

• 79-03-8 propionyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 123-62-6 propionic acid anhydride 
• 802294-64-0 propionic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 943241-49-4 (S_S,2S,3S)-(+)-N-methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfinylamino)pentanamide 
• 943241-42-7 (S_S,2R,3S)-(+)-N-methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfinylamino)pentanamide 
• 163688-09-3 1-[2-(tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone 
• 1138339-21-5 (SS,2R,3S)-(+)-(+)-N-(p-toluenesulfinyl)-3-amino-N-methoxy-N,2-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)pentanamide 
• 121-97-1 4-Methoxypropiophenone 
• 711-33-1 4-trifluoromethyl propiophenone 
• 26672-58-2 1-(4-dimethylaminophenyl)propan-1-one 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 1207459-38-8 C₂₀H₃₂N₂O₅S 
• 1205539-04-3 (R(S),2S,3R)-(-)-N-Methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfonamido)-5-benzyloxypentanamide 
• 1205539-03-2 C₃₀H₄₆N₂O₄S 
• 23757-10-0 1-(5-iodothiophen-2-yl)propan-1-one 
• 637-69-4 4-Methoxystyrene 

Relevant academic research and scientific papers

Enantioselective Mannich Reaction Employing 1,3,5-Triaryl-1,3,5-triazinanes Catalyzed by Chiral-at-Metal Rhodium Complexes

Chiral-at-metal RhIII complexes catalyze the efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol-% of RhIII complex on gram scale without any loss in enantioselectivity.

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3.2-55 nM). A set of carboxylate derivatives demonstrated markedly improved in vitro metabolic stability (t1/2 > 2 h). A selected ligand showed significant in vivo efficacy with 73% of parasitemia reduction in a mouse model. Five new cocrystal structures with PvSHMT were solved at 2.3-2.6 ? resolution, revealing a unique water-mediated interaction with Tyr63 at the end of the para-Aminobenzoate channel. They also displayed the high degree of conformational flexibility of the Cys364-loop lining this channel.

Iron-Catalyzed Michael Addition of Ketones to Polar Olefins

The base metal complex tetrabutylammonium nitrosyltricarbonylferrate {Bu4N[Fe(CO)3(NO)] (TBA[Fe])} – catalyzes the conjugate addition of ketones to polar olefins. The reaction is applicable to a wide range of substrates leading to interesting building blocks for organic synthesis. Clear indications for an acid-base type rather than a C?H activation pathway exist. (Figure presented.).

DERIVATIVES OF 1 H-PYRAZOLO[3,4-B]PYRIDINE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The present invention discloses compounds according to Formula (I): wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds,methods for their production, pharmaceutical

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical

Differential induction of cytoplasmic vacuolization and methuosis by novel 2-indolyl-substituted pyridinylpropenones

Because many cancers harbor mutations that confer resistance to apoptosis, there is a need for therapeutic agents that can trigger alternative forms of cell death. Methuosis is a novel form of nonapoptotic cell death characterized by accumulation of vacuo

Modified shapiro reactions with bismesitylmagnesium as an efficient base reagent

Bismesitylmagnesium has been shown to successfully mediate the Shapiro reaction. A range of tosylhydrazones has been subjected to the developed system, which furnishes exceptionally high incorporation of the introduced electrophiles and good yields of the functionalized styrenes. At conveniently accessible temperatures and with a comparably small excess of base reagent, this protocol offers an efficient alternative to the lithium-mediated process. Importantly, 1.05 equiv of Weinreb amides are sufficient to obtain aryl enones in good yields.

NOVEL HETERO PYRROLE ANALOGS ACTING ON CANNAPINOID RECEPTORS

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.