104863-65-2

Basic information

• Product Name: N-METHOXY-N-METHYL-PROPIONAMIDE
• Synonyms: N-METHOXY-N-METHYL-PROPIONAMIDE
• CAS NO: 104863-65-2
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Mol File: 104863-65-2.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 119°C at 760 mmHg
• Flash Point: 25.8°C
• Appearance: /
• Density: 0.961g/cm³
• Vapor Pressure: 16.3mmHg at 25°C
• Refractive Index: 1.4270 to 1.4310
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-METHOXY-N-METHYL-PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL-PROPIONAMIDE(104863-65-2)
• EPA Substance Registry System: N-METHOXY-N-METHYL-PROPIONAMIDE(104863-65-2)

Safety Data

• RIDADR: UN 1993 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 104863-65-2(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N-methyl-propionamide is a chemical compound with the molecular formula C6H13NO2. It is a clear, colorless liquid with a faint odor and is often used as a solvent in various industrial applications. N-METHOXY-N-METHYL-PROPIONAMIDE is known for its high boiling point and low volatility, making it an effective solvent for a wide range of substances. It is also used as an intermediate in the production of pharmaceuticals and agrochemicals. Additionally, N-methoxy-N-methyl-propionamide has been found to have potential applications in the field of organic synthesis and as a stabilizer for certain chemical reactions. Overall, this chemical compound is valued for its solvent properties and its versatility in various industrial processes.

InChI:InChI=1/C5H11NO2/c1-4-5(7)6(2)8-3/h4H2,1-3H3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 
• 123-62-6 propionic acid anhydride 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 163688-09-3 1-[2-(tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone 
• 164082-78-4 1-[2-(tert-butoxycarbonylamino)-6-methoxyphenyl]-2-butanone 
• 943241-49-4 (S_S,2S,3S)-(+)-N-methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfinylamino)pentanamide 
• 943241-42-7 (S_S,2R,3S)-(+)-N-methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfinylamino)pentanamide 
• 943241-44-9 (2R,3R)-(-)-3-amino-N-methoxy-N,2-dimethyl-3-phenylpropanamide 
• 943241-46-1 (2R,3R)-(+)-N-methoxy-N,2-dimethyl-3-(p-toluenesulfonamido)-3-phenylpropanamide 
• 943241-47-2 (2R,3S)-(+)-N-methoxy-N,2-dimethyl-3-(4-methylphenylsulfonamido)pentanamide 
• 943241-50-7 (2S,3S)-(-)-N-methoxy-N,2-dimethyl-3-(4-methylphenylsulfonamido)pentanamide 
• 121-97-1 4-Methoxypropiophenone 
• 711-33-1 4-trifluoromethyl propiophenone 
• 26672-58-2 1-(4-dimethylaminophenyl)propan-1-one 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 1207459-38-8 C₂₀H₃₂N₂O₅S 

Relevant articles and documents

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3.2-55 nM). A set of carboxylate derivatives demonstrated markedly improved in vitro metabolic stability (t1/2 > 2 h). A selected ligand showed significant in vivo efficacy with 73% of parasitemia reduction in a mouse model. Five new cocrystal structures with PvSHMT were solved at 2.3-2.6 ? resolution, revealing a unique water-mediated interaction with Tyr63 at the end of the para-Aminobenzoate channel. They also displayed the high degree of conformational flexibility of the Cys364-loop lining this channel.

Iron-Catalyzed Michael Addition of Ketones to Polar Olefins

The base metal complex tetrabutylammonium nitrosyltricarbonylferrate {Bu4N[Fe(CO)3(NO)] (TBA[Fe])} – catalyzes the conjugate addition of ketones to polar olefins. The reaction is applicable to a wide range of substrates leading to interesting building blocks for organic synthesis. Clear indications for an acid-base type rather than a C?H activation pathway exist. (Figure presented.).

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical