593280-95-6

Upstream product

• 123-86-4 acetic acid butyl ester 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 852203-18-0 4-chloro-6-(trifluoromethyl)quinolin-2(1H)-one 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 852203-17-9 2,4-dichloro-6-(trifluoromethyl)quinoline 
• 852203-16-8 6-(trifluoromethyl)-4-hydroxyquinolin-2(1H)-one 
• 7574-50-7 N,N'-bis[(4-trifluoromethyl)phenyl]malonodiamide 

Downstream Products

• 275375-54-7 ethyl 3-[4-(5-chloro-2-methoxyphenyl)-6-trifluoromethyl-1,2-dihydro-2-oxoquinolin-3-yl]acrylate 
• 852203-19-1 3-bromo-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 

Relevant academic research and scientific papers

Microwave-assisted multistep synthesis of functionalized 4-arylquinolin-2(1H)-ones using palladium-catalyzed cross-coupling chemistry

Biologically active 4-aryl-3-alkenyl-substituted quinolin-2(1H)-ones have been synthesized in a short and concise manner employing readily available 4-hydroxyquinolin-2(1H)-ones as intermediates. Key steps in the synthesis include the derivatization of th

A mild and efficient synthesis of 4-aryl-quinolin-2(1H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65-96% yield. This method is mild, highly efficient, and amenable to scaleup.