275375-54-7

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 275375-53-6 4-(5-chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinecarboxaldehyde 
• 275375-94-5 3-[[2-[(5-chloro-2-methoxyphenyl)carbonyl]-4-(trifluoromethyl)phenyl]amino]-3-oxopropanoic acid, methyl ester 
• 275375-50-3 4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinecarboxylic acid, methyl ester 
• 568565-34-4 4-(5-chloro-2-methoxy-phenyl)-4-hydroxy-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid methyl ester 
• 275375-51-4 4-(5-chloro-2-methoxyphenyl)-3-(hydroxymethyl)-6-(trifluoromethyl)-2(1H)-quinolinone 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 593280-95-6 4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 7574-50-7 N,N'-bis[(4-trifluoromethyl)phenyl]malonodiamide 
• 852203-18-0 4-chloro-6-(trifluoromethyl)quinolin-2(1H)-one 
• 852203-16-8 6-(trifluoromethyl)-4-hydroxyquinolin-2(1H)-one 
• 852203-17-9 2,4-dichloro-6-(trifluoromethyl)quinoline 
• 852203-19-1 3-bromo-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 140-88-5 ethyl acrylate 

Relevant academic research and scientific papers

Microwave-assisted multistep synthesis of functionalized 4-arylquinolin-2(1H)-ones using palladium-catalyzed cross-coupling chemistry

Biologically active 4-aryl-3-alkenyl-substituted quinolin-2(1H)-ones have been synthesized in a short and concise manner employing readily available 4-hydroxyquinolin-2(1H)-ones as intermediates. Key steps in the synthesis include the derivatization of th

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal

3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention provides novel 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R 1, R 2, R 3, R 4, R 5, R 6 and R 7 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K + channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.