593283-24-0

Upstream product

• 100-52-7 benzaldehyde 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 

Downstream Products

• 1345840-65-4 5-(5-amino-1,3, 4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one 
• 1345840-75-6 3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one 
• 1345840-76-7 5-bromo-3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one 
• 1345840-77-8 3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-5-nitro-1,3-dihydro-2H-indol-2-one 
• 1345840-78-9 5-fluoro-3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one 
• 1345840-79-0 5-iodo-3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one 
• 1345840-80-3 5-chloro-3-{[5-(6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one 
• 1083098-30-9 C₁₄H₁₅N₅O₂ 
• 593283-30-8 5-[5-(4-dimethylamino-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-28-4 6-methyl-5-[5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-yl]-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one 
• 593283-29-5 5-[5-(4-chloro-phenyl)-4H-[1,2,4]triazol-3-yl]-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Synthesis and Characterization of N-substituted pyrimidin-2-one carbohydrazide Derivatives via Microwave-Assisted Approach

The presented research work has brought to limelight the development of an eco-friendly yet rapid synthetic protocol for the assembling of highly reactive N-acylhydrazones possessing significant biological activity via microwave-assisted approach. Owing t

Synthesis of alkoxyphthalimide derivatized oxoimidazolidinyl oxazolo/thiazolo dihydropyrimidine and oxoimidazolidinyl tetrahydropyrimidine via common Schiff base intermediate and evaluation of their antibacterial activity

Synthesis of N-(2-(4-substituted phenyl)-3-(2-(1,3-dioxoisoindolin-2-yloxy)ethyl)-5-oxoimidazolidin-1-yl)-3-(2-(1,3-dioxoisoindolin-2-yloxy)ethyl)-6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides and N-(2-(4-substituted phenyl)-3

Novel approach for synthesis of potent antimicrobial hybrid molecules containing pyrimidine-based imidazole scaffolds

This report describes the novel approach for the synthesis and exploration of hybrid molecules containing pyrimidine-based imidazole scaffolds as potent antimicrobial agents. The targeted compounds N-(4-arylidene-2-mercapto-5-oxo-4,5-dihydro-1H -imidazol-

Design, synthesis and in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antitubercular and antimalarial agents

A series of 5-substituted-3-[{5-(6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4- tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl}-imino]-1,3-dihydro-2H-indol-2- one were synthesized, characterized and screened for their anti-tubercular and antimalarial activity.

1,3-dihydro-2H-indol-2-ones derivatives: Design, Synthesis, in vitro antibacterial, antifungal and antitubercular study

1,3-dihydro-2H-indol-2-ones derivatives are reported to exhibit a wide variety of biodynamic activities such as antituberculer, anti HIV, fungicidal, antibacterial, anticonvulsant. These valid observations led us to synthesize some new indole-2-one deriva

Microwave assisted synthesis and pharmacological screening of novel 6-Methyl-2-oxo-4-substituted 5-(5-Phenyl-1,3,4-oxadiazole-2-yl)-1,2,3, 4-tetrahydropyrimidines

A simple and efficient method has been developed for the synthesis of various 1,3,4-oxadiazole derivatives prepared from DHPM using microwave irradiation technique. The series of 1,3,4-oxadiazole-2-yl-1,2,3,4- tetrahydropyrimidine-2(1H)-one derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for there lipoxygenase inhibitory and antibacterial activities. The results showed that this skeletal framework exhibited marked potency as lipoxigenase inhibition and antibacterial agents. The most active lipoxigenase inhibitor and antibacterial agent was 6-methyl-2-oxo-4-(p-nitrophenyl)-5-(5-phenyl-1,3,4-oxadiazole-2-yl)-1,2,3,4- tetrahydropyrimidine.

Microwave assisted synthesis and characterization of some new annulated pyrimidinone derivatives

4-Aryl-6-methyl-2-pyrimidinone-5-carbohydrazide derivatives have been synthesized from the reaction of different dihydropyrimidinone with hydrazine hydrate. These compounds upon microwave irradiation undergo clean and facile cyclization with chloroacetamide, chloroacetyl chloride and triethylorthoformate and led to the formation of 3-(6-methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,6-dihydro-1,2,4-triazin-5(2H)-one, 4-(6-methyl-2-oxo-4-substitutedphenyl-1,2,3,4-tetrahydropyrimidin-5-yl) tetrahydropyridazine-3,6-dione, 6-methyl-5-(5-oxo-4,5-dihydro-1H-pyrazol-4-yl)- 4-substitutedphenyl-3,4-dihydropyrimidin-2(1H)-one and their substituted derivatives respectively, in quantitative yield. Structures of these newly synthesized compounds were established on the basis of spectra and analytical data.

Synthesis and anti-microbial activity of some pyrimidine derivatives

4-Aryl-5-carboethoxy-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones have been synthesized from easily available starting materials. The carboethoxy group at the C5-position of the pyrimidine ring is converted to corresponding hydrazide which in turn is condensed with cyclising agents such as aromatic aldehydes, CS2 etc. to give fused heterocycles. The fused heterocycles are then subjected to phenacylation to give N3-phenacylpyrimido-heterocycles in excellent yield. In a slightly modified way, uracil derivatives are condensed with ethyl bromoacetate to give N3-β-ethoxycarbonyl derivatives. The hydrazide derivatives of these N3-β-ethoxycarbonyl derivatives subsequently react with 1,2-diketones to give corresponding pyrimido pyridazine derivatives.