59349-86-9

Upstream product

• 7264-90-6 di-morpholin-4-yl-phosphinic acid chloride 
• 364046-84-4 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 

Downstream Products

• 59469-51-1 6-(2-chloro-phenyl)-1-methyl-8-nitro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid 
• 59469-53-3 6-(2-Chlorophenyl)-1-methyl-8-nitro-4H-imidazo[1,5-a][1,4]benzodiazepine maleate 
• 59469-50-0 6-(2-chloro-phenyl)-1-methyl-8-nitro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Phosphorylation of cyclic amides

Compounds of the general formula STR1 are reacted with a strong base followed by a phosphorylating agent, such as dicyclicaminophosphinic halide or bis-di-lower alkylaminophosphinic halide to produce an imine of the formula STR2 wherein R is dicyclicaminophosphinyloxy or bis-di-lower alkylaminophosphinyloxy. R represents a leaving group which will undergo nucleophilic displacement with nitrogen, oxygen, sulfur and carbon containing nucleophiles, that is, nucleophiles which have, as a reactive site, a nitrogen, oxygen, sulfur or carbon atom, such that, when the cyclic imine undergoes nucleophilic displacement, there is formed C--N, C--O, C--S and C--C bonds between the carbon atom of the cyclic imine and the nucleophilic group. The end products may be utilized as intermediates in the production of pharmaceutically valuable compounds and, in some instances, are pharmaceutically valuable compounds per se.