59361-27-2Relevant academic research and scientific papers
Direct18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F-on Phosphonate Prostheses
Wang, Chao,Zhang, Lei,Mou, Zhaobiao,Feng, Wanru,Li, Zhongjing,Yang, Hongzhang,Chen, Xueyuan,Lv, Shengji,Li, Zijing
supporting information, p. 4261 - 4266 (2021/05/26)
We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F- at various hydrogen bond forms. Rapid access to many medicinally significant 18F-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.9-55.1 GBq μmol-1 molar activities both manually or automatically.
Kinetic resolution of P-Chirogenic compounds by palladium-catalyzed alcoholysis of vinyl ethers
Itoh, Hisashi,Yamamoto, Eiji,Masaoka, Shigeyuki,Sakai, Ken,Tokunaga, Makoto
supporting information; experimental part, p. 1796 - 1800 (2011/03/18)
The palladium-catalyzed asymmetric alcoholysis of vinyl ethers of P-chirogenic compounds has been achieved. The kinetic resolution of aryl tert-butyl(2-vinyloxyaryl)phosphinates was catalyzed by palladium/chiral diamine complexes with high selectivities (
Synthesis, fungitoxicity and QSAR study of O,O-bis(aryl)iso-butyl phosphonates
Samanta, Srikanta,Roy, Nripendra K.
, p. 564 - 571 (2007/10/03)
Twentyfour new compounds of the series O,O-bis(aryl) iso-butyl phosphonates have been synthesised and tested for fungitoxicity in vitro on four phytopathogenic fungi. The phosphonates in general, exhibited higher activity on Pythium aphanidermatum (Eds.)
