59383-65-2

Upstream product

• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 1122-91-4 4-bromo-benzaldehyde 
• 106-54-7 p-Chlorothiophenol 
• 586-75-4 4-chlorobenzoyl chloride 
• 100874-02-0 <4-Brom-phenacyl>-<4-chlor-phenyl>-sulfid 

Downstream Products

• 54118-75-1 4-bromo-4'-methoxybenzophenone 
• 844879-16-9 (4-bromophenyl)(3,5-dimethylphenyl)methanone 

Relevant academic research and scientific papers

Metal-free cross-coupling reaction of aldehydes with disulfides by using DTBP as an oxidant under solvent-free conditions

A DTBP-promoted C-H thiolation of aldehydes with disulfides under metal-free and solvent-free conditions is described. The system shows good functional group tolerance to afford thioesters in moderate to excellent yields. the Partner Organisations 2014.

Synthesis of thioesters through copper-catalyzed coupling of aldehydes with thiols in water

Copper-catalyzed C-S bond formation between aldehydes and thiols in the presence of TBHP as an oxidant is described. Functional groups including chloro, trifluoromethyl, bromo, iodo, nitrile, ester and thiophene are all tolerated by the reaction condition

Palladium-catalyzed coupling of thiol esters with aryl and primary and secondary alkyl organoindium reagents

Thiol esters and organoindium reagents undergo palladium-catalyzed cross-coupling under mild conditions to give ketones in moderate to excellent yields. Aryl and primary/ secondary alkyl organoindium reagents can be used as coupling partners. This method has two advantages over the cross-coupling of thiol esters with boron and tin reagents: (1) no added copper reagent is required to mediate the reaction and (2) for the case of alkyl transfer, no added base is required to activate organoindium reagents for cross-coupling as is required for the coupling of alkyl boron reagents with thiol esters.