54118-75-1

Basic information

• Product Name: 4-BROMO-4'-METHOXYBENZOPHENONE
• Synonyms: CHEMBRDG-BB 5314129;(4-BROMO-PHENYL)-(4-METHOXY-PHENYL)-METHANONE;4-BROMO-4'-METHOXYBENZOPHENONE
• CAS NO: 54118-75-1
• Molecular Formula: C₁₄H₁₁BrO₂
• Molecular Weight: 291.14
• Mol File: 54118-75-1.mol
• Article Data: 44

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 393.4 °C at 760 mmHg
• Flash Point: 191.7 °C
• Appearance: /
• Density: 1.401 g/cm³
• Vapor Pressure: 2.14E-06mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 4-BROMO-4'-METHOXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-4'-METHOXYBENZOPHENONE(54118-75-1)
• EPA Substance Registry System: 4-BROMO-4'-METHOXYBENZOPHENONE(54118-75-1)

Safety Data

• Hazardous Substances Data: 54118-75-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-4'-methoxybenzophenone, also known as 4-(4-Bromophenyl)-4-methoxybenzophenone, is a chemical compound that belongs to the class of benzophenones. It is a white to off-white crystalline solid with a molecular formula of C14H11BrO2. 4-BROMO-4'-METHOXYBENZOPHENONE is used as a photoinitiator in the production of inks, adhesives, and coatings, where it initiates chemical reactions when exposed to ultraviolet or visible light. It is a versatile compound with applications in the fields of polymer chemistry, materials science, and pharmaceuticals. Additionally, it is utilized as an intermediate in the synthesis of various other organic compounds. However, it is important to handle 4-Bromo-4'-methoxybenzophenone with care, as it may be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

InChI:InChI=1/C14H11BrO2/c1-17-13-8-4-11(5-9-13)14(16)10-2-6-12(15)7-3-10/h2-9H,1H3

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 100-66-3 methoxybenzene 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 586-75-4 4-chlorobenzoyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 66107-30-0 4-bromophenyl trifluoromethanesulfonate 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 5467-74-3 4-Bromophenylboronic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 838-21-1 (4-bromophenyl)(4-methoxyphenyl)methanol 
• 53039-48-8 1-(4-bromobenzyl)-4-methoxybenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 75607-30-6 (4-Bromo-phenyl)-(4-dimethylamino-phenyl)-(4-methoxy-phenyl)-methanol 
• 4369-50-0 4-hydroxyphenyl-(4-bromo-phenyl)-methanone 
• 27645-60-9 4-(4-methoxybenzoyl)benzonitrile 
• 103162-12-5 2,2-Dianisyl-2-(4-brom-phenyl)-4'-brom-acetophenon 
• 115096-73-6 4-(4,4'-dibromo-stilben-α-yl)-anisole 
• 1010071-28-9 C₂₁H₂₄Br₂O₂ 
• 192437-85-7 [4-[6-bromohexyloxy]phenyl](4-bromophenyl)methanone 
• 192437-50-6 [4-(6-azidohexyloxy)phenyl](4-bromophenyl)methanone 
• 579816-00-5 (4-bromophenyl)-[4-(6-cyclopropylaminohexyloxy)phenyl]methanone 
• 192437-28-8 (4-bromo-phenyl)-[4-[6-[(3-hydroxy-propyl)-amino]-hexyloxy]-phenyl]-methanone 
• 579816-36-7 N-{6-[4-(4-bromobenzoyl)phenoxy]hexyl}-N-cyclopropyl-2,2,2-trifluoroacetamide 
• 4306-46-1 4-Brom-4'-acetoxy-benzophenon 

Relevant articles and documents

Thiophenol detection using an AIE fluorescent probe through self-assembly with TPE-based glycoclusters

We describe a novel green-emitting tetraphenylethylene-dicyanomethylene-4H-pyran (TPE-DCM) based fluorescent probe (TD-1). Conjugating TPE and DCM moieties allowed TD-1 to display high selectivity for thiophenol with excellent AIE properties in aqueous so

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.

Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes

The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.