59417-88-8Relevant academic research and scientific papers
HISTONE DEACETYLASE INHIBITORS BASED ON ALPHACHALCOGENMETHYLCARBONYL COMPOUNDS
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Page column 17, (2008/06/13)
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-chalcogenmethylcarbonyl group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington’s disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or for stimulating hematopoietic cells ex vivo.
An alternative procedure for the O-trimethylsilylation of enolates generated by copper-catalyzed 1,4-additions
Andringa,Oosterveld,Brandsma
, p. 1393 - 1396 (2007/10/02)
Anhydrous lithium bromide has been successfully used as an additive instead of hexamethylphosphoric triamide in the O-trimethylsilation of enolates generated by copper halide-catalyzed reaction of Grignard reagents with a number of α,β-unsaturated carbony
Me3SiCl/HMPA ACCELERATED CONJUGATE ADDITION OF CATALYTIC COPPER REAGENT. STEREOSELECTIVE SYNTHESIS OF ENOL SILYL ETHER OF ALDEHYDE
Horiguchi, Yoshiaki,Matsuzawa, Satoshi,Nakamura, Eiichi,Kuwajima, Isao
, p. 4025 - 4028 (2007/10/02)
Copper-catalyzed conjugate addition of Grignard reagents in the presence of Me3SiCl and HMPA proceeds in much higher yield than the reaction of conventional organocopper reagents and shows very good regio-, stereo-, and chemoselectivities.
