59424-95-2Relevant academic research and scientific papers
Method for synthesizing 4-methylaminocrotonate
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Paragraph 0025; 0026; 0027; 0028; 0029; 0030; 0031-0036, (2019/04/26)
The invention discloses a technology for synthesizing 4-methylaminocrotonate. The technology comprises the specific steps that methyl 4-bromocrotonate, methyl alcohol and a catalyst are added into a sealed reactor, heating is performed to perform a reaction under the temperature of 65 DEG C or above, after raw materials react completely, a reaction solution is cooled, then filtering is performed,solid by-products are removed, a filtrate is concentrated, excessive methyl alcohol is recycled, the obtained concentrated solution crude product is subjected to reduced pressure distillation purification, and the 4-methylaminocrotonate with the high purity can be obtained; the technology is adopted for synthesizing 4-methylaminocrotonate, the raw material 4-bromocrotonate is completely converted,post-processing operation is simplified, the reaction yield is increased, and the production cost is remarkably lowered.
IDO INHIBITORS
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Paragraph 1746, (2016/10/27)
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS
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Page 45, (2010/02/07)
This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.
Synthesis of Some Polyfunctionalized Bicyclononane-2,9-diones and Bicyclodecane-2,10-diones
Harding, Kenn E.,Clement, Beverly A.,Moreno, Louis,Peter-Katalinic, Jasna
, p. 940 - 948 (2007/10/02)
Methods for synthesis of 7,7-disubstituted bicyclodec-3-ene-9,10-dione derivatives 2, synthons for synthesis of elemanolide sesquiterpenes, and related bicyclononanedione systems were developed.It was determined that reaction of electrophili
