59429-73-1

Upstream product

• 2401-24-3 2-chloro-5-methoxyaniline 
• 953045-33-5 bis(2-chloro-5-methoxyphenyl)disulfide 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 140-89-6 potassium ethyl xanthogenate 
• 2732-80-1 2-bromo-1-chloro-4-methoxybenzene 

Downstream Products

• 142406-11-9 3-(2-chloro-5-methoxyphenylthio)propanoic acid 
• 1035797-58-0 3-(2-Chloro-5-methoxy-phenylsulfanyl)-pentanedioic acid dimethyl ester 
• 70098-60-1 (5aR,6aS,7R)-1,8,11-Trihydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide 
• 70098-60-1 (5aS,6aS,7R)-1,8,11-Trihydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide 
• 70098-60-1 (5aR,6aS,7S)-1,8,11-Trihydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide 
• 74213-32-4 (5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide 
• 70098-59-8 4-[2-(5-Hydroxy-4-oxo-thiochroman-2-yl)-eth-(Z)-ylidene]-2-phenyl-4H-thiazol-5-one 
• 59429-75-3 EMD 36927 
• 59429-74-2 3-(2-Chloro-5-methoxy-phenylsulfanyl)-pentanedioic acid 

Relevant academic research and scientific papers

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enone using structure-based design strategies resulted in inhibitors with considerable improvement in biochemical potency against human lactate dehydrogenase A (LDHA). These potent inhi

Furan Derivatives. Part 13. Synthesis of Thiopyranobenzofuran

Thiopyranobenzofuran 9 possessing benzofuran and methylenethiopyran structures in the molecule was synthesized starting from 1-chloro-4-methoxy-2-nitrobenzene 11.Some reactions (formylation, protonation and catalytic hydrogenation) on 9 were examined.The 2-position of 9 was highly reactive toward electrophilic reagents and the furan ring was readily reduced by catalytic hydrogenation with palladium-charcoal.Thiopyranobenzofuran 9 has both properties of methylenethiopyran and benzofuran.

Tetracyclic compounds

Tetracyclic compounds of the formula STR1 wherein R1, R2, R3 and R4 each are H or alkyl, R5 is H, F, Cl, Br, CF3, OH, alkyl, alkoxy, NO2, NH2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R5 is methoxy and X is a sulfur atom, R5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.