59452-81-2

Upstream product

• 30309-80-9 di-o-tolylphosphine oxide 
• 62-53-3 aniline 
• 36042-94-1 bis(o-tolyl)chlorophosphine 
• 932-31-0 ortho-tolylmagnesium bromide 
• 172208-66-1 ethyl bis(2-methylphenyl)phosphinate 

Downstream Products

• 1454909-05-7 N-phenyl-1-methylphenyl-3,4-di(p-methoxyphenyl)-1,2-dihydro-8-methylbenz[c-1,2]azaphosphinine 1-oxide 
• 18593-19-6 bis(2-methylphenyl)phosphinic acid 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Rhodium-catalyzed oxidative coupling through C-H activation and annulation directed by phosphonamide and phosphinamide groups

Rhodium-catalyzed oxidative coupling reactions via C-H activation and annulation directed by phosphonamide and phosphinamide groups were developed under aerobic conditions, which produced benzazaphosphole 1-oxides and phosphaisoquinolin-1-oxides.

Hydrolysis of Diarylphosphinic Amides in Acidic Solution: Steric Inhibition and Mechanism

The pseudo-first-order rate constants for the hydrolysis of diphenylphosphinic amide Ph2P(O)NH2 and its di-p-tolyl, di-o-tolyl, and dimesityl analogues (106kψ 3 630, 2 340, 81.0, and 3.27 s-1 respectively with H(1+) 0.0662M and T 30.2 deg C) in water-dioxan (9:1 v/v) containing perchloric acid show that reaction is sterically hindered by ortho-methyl substituents in the P-aryl groups.Steric inhibition is as great, or greater, in the hydrolysis of the corresponding (N-phenyl)diarylphosphinic amides (106kψ 5 440, 4 470, 54.9 and 0.88 s-1 respectively with H(1+) 1.36M and T 39.9 deg C) and (N-p-nitrophenyldiarylphosphinic amides (106kψ 724, 702, 6.57, and 0.098 s-1 respectively with H(1+) 2.58M and T 39.9 deg C) even though the departing amine is less nucleophilic.Such sensitivity to steric hindrance is consistent with associative (A2) mechanism for the hydrolysis of all the substrates.