59477-80-4

Upstream product

• 253185-03-4 tert-butylbenzene 
• 141-75-3 butyryl chloride 
• 71-43-2 benzene 
• 772-38-3 4-tert-Butylphenylacetylene 
• 97-93-8 triethylaluminum 
• 64-18-6 formic acid 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 106-94-5 propyl bromide 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 123-72-8 butyraldehyde 
• 38675-79-5 (4-(tert-butyl)phenyl)(cyclopropyl)methanone 

Downstream Products

• 14107-87-0 1-(4-tert-butyl-phenyl)-butan-1-ol 
• 14011-00-8 4-tert-butyl-1-n-butylbenzene 
• 1253040-82-2 C₁₄H₁₉BrO 
• 1189758-21-1 C₁₈H₁₈N₄ 
• 1253040-88-8 1-(4-tert-butylphenyl)butane-1,2-dione 
• 1253040-85-5 1-(4-(tert-butyl)phenyl)-2-hydroxybutan-1-one 

Relevant academic research and scientific papers

Acylation of aryl halides and α-bromo acetates with aldehydes enabled by nickel/tbadt cocatalysis

In this protocol aryl halides and α-bromo acetates are efficiently cross-coupled with an array of (hetero)aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provides a concise approach to a variety of ketones with high compatibility of various functional groups.

Palladium-Catalyzed Carbonylative Coupling of Aryl Iodides with Alkyl Bromides: Efficient Synthesis of Alkyl Aryl Ketones

Alkyl aryl ketones are important structures with applications in many areas of chemistry. Hence, efficient procedures for their production are particularly attractive. In this communication, a general and efficient carbonylative cross-coupling of aryl iodides and unactivated alkyl bromides is presented. By using a simple palladium catalyst, a series of alkyl aryl ketones were synthesized in moderate to excellent yields from readily available alkyl and aryl halides in an In-Ex tube with formic acid as the CO source. In this study both primary and secondary alkyl bromides/iodides were suitable coupling partners. Additionally, this method can also be employed for the late-stage functionalization of complex natural products and polyfunctionalized molecules. (Figure presented.).

Iodine promoted α-hydroxylation of ketones

A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydroxylation of aryl ketones using a sub-stoichiometric amount of molecular iodine.

Alkylalumination of arylacetylene catalyzed by zirconocene catalysts supported on solid materials

Zirconocene dichloride (Cp2ZrCl2) supported on montmorillonite K-10, which has previously been shown to be an efficient catalytic system for olefin polymerization, was found to be comparable to the highly activated homogeneous combin

Samarium diiodide induced reactions of cyclopropyl ketones: Reductive ring cleavage and dimerization leading to 1,8-diketones - Scope, limitations, mechanisms

Reactions of the samarium diiodide/HMPA complex with alkyl cyclopropyl ketones such as 3, 5, and 7 provided dimers incorporating a 1,8-diketone moiety. The products 4, 6, and 8 were isolated in moderate to good yields. The aryl-substituted cyclopropyl ketones afforded a broader product spectrum, which results from the attack of samarium intermediates to the aryl group. Cyclopropyl phenyl ketone (13) gave dimer 14, where one cyclopropane ring was reductively cleaved, whereas the second one is still present. The reductive dimerization of cyclopropyl 2-thienyl ketone (21) furnished the product 22, which still contains two cyclopropyl groups. Further examples demonstrate the diversity of samarium diiodide induced reductions of cyclopropyl ketones. Plausible reaction mechanisms involving samarium ketyl intermediates are presented. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Process for the manufacture of ketones

Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalide, in methylene chloride as the solvent, at a temperature between about 20° and about 100° C., preferably between about 30° and about 60° C., more preferably of about 40° C. which is the reflux temperature of the methylene chloride. When operating at a temperature above approximately 40° C., pressure higher than atmospheric is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.

P-tert-butyl-diphenylalkane insecticides

1,1-Diphenylalkanes having a p-tert-butyl and a p'-alkoxy group substituted thereon are a novel class of compounds having a broad range of insecticidal activity.

P-Tert-butyl-diphenylalkane insecticides

1,1-Diphenylalkanes having a p-tert-butyl and a p'-alkyl group substituted thereon are a new class of compounds possessing a broad range of insecticidal activity.