59480-95-4Relevant academic research and scientific papers
Direct Synthesis of Secondary Benzylic Alcohols Enabled by Photoredox/Ni Dual-Catalyzed Cross-Coupling
Alam, Rauful,Molander, Gary A.
, p. 13728 - 13734 (2017)
An operationally simple, mild, redox-neutral method for the cross-coupling of α-hydroxyalkyltrifluoroborates is reported. Utilizing an Ir photocatalyst, α-hydroxyalkyl radicals are generated from the single-electron oxidation of the trifluoroborates, and these radicals are subsequently engaged in a nickel-catalyzed C-C bond-forming reaction with aryl halides. The process is highly selective, functional group tolerant, and step economical, which allows the direct synthesis of secondary benzylic alcohol motifs.
1-(P-Alkanoylphenyl) alkanols and derivatives
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, (2008/06/13)
1-(p-alkanoylphenyl) alkanols, e.g., 1-(p-acetophenyl)-2,2-dimethylpropanol, are prepared from p-alkanoylphenyl Grignard reagents and alkyl and aryl aldehydes or acyl or aroyl halides and are useful as hypolipidemic and anti-diabetic agents.
α-Substituted-4-(2,2-dimethyl-1-hydroxypropyl)benzyl alcohols and esters
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, (2008/06/13)
α-substituted-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohols and esters, e.g., α-methyl-4-(2,2-dimethyl-1-hydroxypropyl) benzyl alcohol, are prepared from the corresponding 1-(4-alkanoylphenyl) alkanols and derivatives and are useful as hypolipidemic ag
