594837-61-3

Basic information

• Product Name: (2R,1'S)-2-hydroxymethyl-2-methyl-3-phenyl-N-(1'-phenylethyl)propionamide
• CAS NO: 594837-61-3
• Molecular Weight: 297.397
• Mol File: 594837-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,1'S)-2-hydroxymethyl-2-methyl-3-phenyl-N-(1'-phenylethyl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,1'S)-2-hydroxymethyl-2-methyl-3-phenyl-N-(1'-phenylethyl)propionamide(594837-61-3)
• EPA Substance Registry System: (2R,1'S)-2-hydroxymethyl-2-methyl-3-phenyl-N-(1'-phenylethyl)propionamide(594837-61-3)

Safety Data

• Hazardous Substances Data: 594837-61-3(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 594837-44-2 2-hydroxymethyl-2-methyl-3-phenylpropanoic acid 
• 2109-99-1 2-benzyl-2-methyl-1,3-propanediol 
• 55114-30-2 2-benzyl-2-methylmalonic acid diethyl ester 
• 100-39-0 benzyl bromide 
• 594837-83-9 2-acetoxymethyl-2-methyl-3-phenylpropanoic acid 
• 594837-80-6 2-acetoxymethyl-2-methyl-3-phenylpropanol 

Downstream Products

• 656241-09-7 (S)-2-acetylsulfanylmethyl-2-methyl-3-phenylpropanoic acid 
• 656241-07-5 (S)-2-bromomethyl-2-methyl-3-phenylpropanoic acid 

Relevant articles and documents

Synthesis and evaluation of α,α -disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design

2-Ethyl-2-methyl-3-mercaptopropanoic acid (6) and 2-benzyl-2-methyl-3-mercaptopropanoic acid (7) were synthesized and evaluated as inhibitors for carboxypeptidase A (CPA), a prototypical zinc protease with the expectation that the binding affinities of these inhibitors would be augmented over those of 2-ethyl-3-methylsuccinic acid (2) and 2-benzyl-3-methylsuccinic acid (3), respectively, in light of the fact that the sulfhydryl group is a better zinc coordinating moiety than the carboxylate group. Contrary to the expectation, however, the inhibitory potency of 6 was not improved and that of 7 was rather attenuated by the replacement. A probable explanation for the unexpected results is offered.