594847-83-3

Upstream product

• 108-22-5 Isopropenyl acetate 
• 80174-16-9 1-(4’-methoxyphenyl)butan-1,4-diol 
• 5447-74-5 methyl 3-(4-methoxybenzoyl)propionate 
• 26153-41-3 γ-(4-methoxyphenyl)-γ-butyrolactone 

Downstream Products

• 594847-89-9 (S)-1-(4’-methoxyphenyl)butan-1,4-diol 
• 128994-28-5 (S)-(-)-γ-(p-Methoxyphenyl)-γ-butyrolactone 

Relevant academic research and scientific papers

Application of a one-pot lipase resolution strategy for the synthesis of chiral γ- and δ-lactones

A successful one-pot reduction of γ-ketoesters, δ-ketoesters and lactones to the corresponding 1,4- and 1,5-diols followed by a lipase catalyzed kinetic resolution coupled with hydrolysis to afford optically active diols is described. The synthetic utility of this one-pot method was illustrated by the oxidation of these chiral diols to respective chiral γ-butyrolactone and δ-lactones. Lipase from Pseudomonas cepacia, immobilized on ceramic afforded the product with high enantiomeric excess in good yields under mild reaction conditions. This approach has been used to develop a convenient enantioselective route for several γ- and δ-lactones using achiral and corresponding racemic starting material.