6728-21-8

Basic information

• Product Name: allyl methanesulfonate
• Synonyms: 3-(Mesyloxy)-1-propene;Methanesulfonic acid allyl ester;Methanesulfonic acid=allyl ester;allyl methanesulfonate;ALLYLMETHANESULPHONATE;PROP-2-EN-1-YL METHANESULFONATE
• CAS NO: 6728-21-8
• Molecular Formula: C₄H₈O₃S
• Molecular Weight: 136.18
• Mol File: 6728-21-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 220.45°C (rough estimate)
• Flash Point: 93.6°C
• Appearance: /
• Density: 1.283 (estimate)
• Vapor Pressure: 0.0962mmHg at 25°C
• Refractive Index: 1.4640 (estimate)
• CAS DataBase Reference: allyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: allyl methanesulfonate(6728-21-8)
• EPA Substance Registry System: allyl methanesulfonate(6728-21-8)

Safety Data

• Hazardous Substances Data: 6728-21-8(Hazardous Substances Data)

Usage

General Description

Allyl methanesulfonate is an organic compound that is used as a mutagen in genetic research. It is a colorless liquid with a pungent odor and is highly reactive due to the presence of the allyl group. Allyl methanesulfonate is primarily used in studies to induce mutations in DNA and to investigate the effects of these mutations on gene expression and protein function. Its mutagenic properties make it a valuable tool in the field of molecular genetics, as it allows researchers to manipulate and study the genetic material of various organisms. However, its use also presents potential health hazards and requires careful handling and disposal to minimize the risks of exposure.

InChI:InChI=1/C4H8O3S/c1-3-4-7-8(2,5)6/h3H,1,4H2,2H3

Upstream product

• 20907-32-8 sodium allyloxide 
• 124-63-0 methanesulfonyl chloride 
• 107-18-6 allyl alcohol 
• 7143-01-3 Methanesulfonic anhydride 
• 107-19-7 propargyl alcohol 
• 106-95-6 allyl bromide 

Downstream Products

• 4165-79-1 1,1-diphenyl-3-buten-1-ol 
• 300-57-2 allylbenzene 
• 83604-75-5 2-(1-Allyl-4-hydroxy-piperidin-4-yl)-N-cyclohexyl-N-methyl-propionamide 
• 73735-22-5 (1-Allyl-piperidin-4-yl)-(3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-amine 
• 15258-46-5 N-allyl-p-toluidine 
• 3480-96-4 N,N-diallyl-p-toluidine 
• 71954-46-6 N-allyl-4-methoxyaniline 
• 59318-70-6 N,N-diallyl-4-methoxyaniline 
• 24165-63-7 1-p-tolyl-3-buten-1-ol 
• 14506-33-3 1-(4-chlorophenyl)but-3-en-1-ol 
• 67472-22-4 methyl 4-(1-hydroxybut-3-enyl)benzoate 
• 69036-26-6 1-cyclohexyl-3-buten-1-ol 
• 5263-58-1 N-allylphenethylamine 
• 589-09-3 N-allyl-N-phenylamine 

Relevant articles and documents

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Efficient synthesis of organic thioacetates in water

Thioacetates as precursors of thiols are interesting starting points for synthesizing other organosulfur compounds. Herein, we propose a simple, efficient and fast method to obtain organic thioacetates using water as a solvent. Taking into account the great attention that has been paid toward environmentally friendly synthetic procedures in the past decades, we prove the role and the strength of the thioacetate anion as a nucleophile for nucleophilic displacement reactions in an aqueous medium. The reactions were carried out under pH control, to prevent the decomposition of the mesylate starting materials, using potassium carbonate as a safe and mild base. A simple work up allows products to be obtained with excellent yield and acceptable purity.

A 2 - ((4R, 6S) - 6-substituted methyl-2-substituent -1,3-dioxane-4-yl) acetate preparation method

The invention relates to a method for preparing 2-((4R, 6S)-6-substituted methyl-2-substituent group-1,3-dioxane-4-yl) acetate. The method comprises the following steps: by utilizing substituted ethylene and 3,3-dialkoxy propionate or 3-alkoxy acrylate, preparing 2-((4R, 6S)-6-substituted methyl-2-ester group methyl-1,3-dioxane-4-yl) acetate under catalysis of a Lewis acid; and preparing ethyl 2-((4R, 6S)-6-chloromethyl-2-substituted phenyl-1,3-dioxane-4-yl) acetate through hydrolysis ring opening and ring formation protection, performing hydrolysis ring opening again, performing ring formation protection with a carbonyl compound X or glycol XI thereof, and thus obtaining 2-((4R, 6S)-6-substituted methyl-2-substituent group-1,3-dioxane-4-yl) acetate. A chiral center is established by utilizing an equatorial bond stable form of a six-membered ring chair structure, and a chiral auxiliary reagent is not additionally used. The raw materials are readily available, the reaction process is short, asymmetric reduction of carbonyl is avoided, flammable and combustible reducing agents are not used, and the preparation method is easy, convenient, environment-friendly and suitable for large-scale industrial production.