594872-24-9Relevant academic research and scientific papers
A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones
Betori, Rick C.,Miller, Eric R.,Scheidt, Karl A.
supporting information, p. 1131 - 1137 (2017/04/11)
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in acc
One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids
Lebedyeva, Iryna O.,Biswas, Suvendu,Goncalves, Kevin,Sileno, Sean M.,Jackson, Ashton R.,Patel, Kunal,Steel, Peter J.,Katritzky, Alan R.
supporting information, p. 11695 - 11698 (2014/10/15)
Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a C-H bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.
Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles
Katritzky, Alan R.,Cai, Chunming,Singh, Sandeep K.
, p. 3375 - 3380 (2007/10/03)
Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.
