2719-26-8

Basic information

• Product Name: Cyclohexanecarboxamide, N-phenyl-
• Synonyms: Cyclohexanecarboxamide, N-phenyl-
• CAS NO: 2719-26-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• Mol File: 2719-26-8.mol
• Article Data: 98

Chemical Properties

• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 232.2°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 3.32E-06mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: Cyclohexanecarboxamide, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxamide, N-phenyl-(2719-26-8)
• EPA Substance Registry System: Cyclohexanecarboxamide, N-phenyl-(2719-26-8)

Safety Data

• Hazardous Substances Data: 2719-26-8(Hazardous Substances Data)

Usage

General Description

Cyclohexanecarboxamide, N-phenyl- is a chemical compound that belongs to the amide group. It is also known as N-phenylcyclohexanecarboxamide and is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is a white solid with a molecular formula of C13H17NO and a molecular weight of 203.28 g/mol. This chemical is also used as a building block in the synthesis of other organic compounds and has applications in the field of organic synthesis and chemical research. It is important to handle this compound with care and follow safety guidelines due to its potential hazards and risks.

InChI:InChI=1/C13H17NO/c15-13(11-7-3-1-4-8-11)14-12-9-5-2-6-10-12/h2,5-6,9-11H,1,3-4,7-8H2,(H,14,15)

Upstream product

• 103-71-9 phenyl isocyanate 
• 931-50-0 cyclohexylmagnesium bromide 
• 62-53-3 aniline 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 
• 4904-55-6 cyclohexanecarbonyl peroxide 
• 538-75-0 dicyclohexyl-carbodiimide 
• 3743-70-2 N-(2-hydroxyphenyl)benzamide 
• 100-09-4 4-methoxybenzoic acid 
• 701-73-5 methyl N-phenyldithiocarbamate 
• 10500-30-8 cyclohexanoyl bromide 
• 201230-82-2 carbon monoxide 
• 626-62-0 Cyclohexyl iodide 

Downstream Products

• 101090-33-9 2-cyclohexyLiDene-3-phenyl-oxazolidine-4,5-dione 
• 4664-67-9 <1-Chlor-cyclohexyl>-<4-dimethylamino-phenyl>-keton 
• 6064-01-3 Cyclohexanecarbonyl-phenyl-carbamic acid isopropyl ester 
• 1613-43-0 2-cyclohexylquinoline 
• 106989-85-9 2-phenyl-2-aza-spiro[4.5]decane-1,3,4-trione 
• 1360571-16-9 2,4-dichlorophenyl N-phenylcyclohexanecarboximidate 
• 1354550-00-7 difluoromethyl N-phenyl-1-cyclohexylmethanimidate 
• 1262796-62-2 C₂₃H₂₃NO 
• 4664-73-7 1-Chlor-cyclohexan-1-carbonsaeure-anilid 
• 126541-71-7 N-cyclohexylmethyl-aniline; hydrochloride 
• 548763-46-8 N-(4-hydroxyphenyl)cyclohexanecarboxamide 
• 220383-46-0 N-(2-trifluoromethylphenyl)cyclohexanecarboxamide 
• 315712-26-6 N-(4-methoxyphenyl)-cyclohexanecarboxamide 
• 200706-63-4 N-(4-iodophenyl)cyclohexanecarboxamide 

Relevant articles and documents

Copper-Catalyzed Carbonylative Coupling of Cycloalkanes and Amides

Carbonylation reactions are a most powerful method for the synthesis of carbonyl-containing compounds. However, most known carbonylation procedures still require noble-metal catalysts and the use of activated compounds and good nucleophiles as substrates.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.