59488-39-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
Ethane, 1,1,1-trifluoro-2-isothiocyanatois utilized as a key reagent in the synthesis of various pharmaceuticals and agrochemicals. Its unique properties allow for the creation of a wide range of products that can address diverse medical and agricultural needs.
Used in Organic Synthesis:
As a reagent in organic synthesis, Ethane, 1,1,1-trifluoro-2-isothiocyanatois employed to facilitate chemical reactions that lead to the formation of desired organic compounds. Its presence can enhance the efficiency and selectivity of these reactions, making it an indispensable tool in the synthesis of complex organic molecules.
Used in Industrial Manufacturing:
Ethane, 1,1,1-trifluoro-2-isothiocyanatoalso serves as a raw material in the manufacturing of various industrial products. Its application in this sector underscores its broad utility and the reliance of the industry on its unique chemical characteristics.
Used as a Solvent:
In some applications, Ethane, 1,1,1-trifluoro-2-isothiocyanatois used as a solvent. Its properties make it suitable for dissolving certain substances, which can be crucial in specific chemical processes and reactions.
Safety Considerations:
It is important to handle Ethane, 1,1,1-trifluoro-2-isothiocyanatowith care due to its potential harmful effects on human health when exposed to high concentrations. Proper safety measures and precautions should be taken to mitigate any risks associated with its use.

Upstream product

• 75-15-0 carbon disulfide 
• 753-90-2 trifluoroethylamine 

Relevant academic research and scientific papers

Preparation method of trifluoroisothiocyanate ethane

The invention relates to a preparation method of trifluoroisothiocyanate ethane. The preparation method comprises the steps of 1, mixing trifluoroethylamine, triethylamine and a solvent to obtain a first reaction mixture; controlling the temperature to be 10-12 DEG C, adding carbon disulfide, and reacting at the temperature of 5-20 DEG C to obtain a second reaction mixture containing trifluoroethylamino thioformate, wherein the molar ratio of the trifluoroethylamine to the triethylamine is 1: (1.05-2), the molar ratio of trifluoroethylamine to carbon disulfide is 1: (1-1.2), the molar ratio of trifluoroethylamine to the solvent is 1: (5-8), and the solvent is toluene, xylene or dichloromethane; 2, cooling the second reaction mixture obtained in the step 1 to 5-10 DEG C, adding solid light, stirring at room temperature, heating to the temperature of 35-45 DEG C, and reacting to obtain a trifluoroisothiocyanate ethane mixture; and then cooling, adding water and rectifying to obtain trifluoroisothiocyanate ethane. Compared with the prior art, the method has the advantages of high product yield and less three wastes by adopting solid light as a catalyst. According to the method, toluene/dichloromethane is adopted as the solvent, the problems that tetrahydrofuran and water are mixed and dissolved, part of products are brought into a water phase, the reaction yield is too low, and the solvent is difficult to recover are solved, the solvent can be recovered and reused after being evaporated, the recovery rate reaches 88% or above, the reaction cost is reduced, and emission of three wastes is reduced.

AZOLE COMPOUNDS AS PIM INHIBITORS

The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further em