59490-28-7Relevant academic research and scientific papers
Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates
Chen, Jianzhong,Gridnev, Ilya D.,Hu, Yawen,Li, Bowen,Zhang, Wanbin,Zhang, Zhenfeng
supporting information, p. 5371 - 5375 (2020/02/15)
Earth-abundant nickel, coordinated with a suitable chiral bisphosphine ligand, was found to be an efficient catalyst for the asymmetric hydrogenation of 2-amidoacrylates, affording the chiral α-amino acid esters in quantitative yields and excellent enantioselectivity (up to 96 % ee). The active catalyst component was studied by NMR and HRMS, which helped us to realize high catalytic efficiency on a gram scale with a low catalyst loading (S/C=2000). The hydrogenated products could be simply converted into chiral α-amino acids, β-amino alcohols, and their bioactive derivatives. Furthermore, the catalytic mechanism was investigated using deuterium-labeling experiments and computational calculations.
Synthesis of Isomeric Methyl- and Dimethyl-Substituted 4-Benzylidene-2-phenyloxazolin-5-ones and Ring-Opened Derivatives
Nicholas, Everton S.,Phelps, David J.
, p. 89 - 90 (2007/10/02)
4-Benzylidene-2-phenyloxazolin-5-one and 15 mono- and dimethylated isomers as well as their ring-opened methyl ester and acid derivatives have been synthesized.Absorption spectroscopy indicates insignificant changes in the chromophore due to the methyl groups.
