59507-54-9

Basic information

• Product Name: 2-chloro-N-cyclohexylbenzamide
• Synonyms: 2-chloro-N-cyclohexylbenzamide
• CAS NO: 59507-54-9
• Molecular Formula: C₁₃H₁₆ClNO
• Molecular Weight: 237.72524
• Mol File: 59507-54-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 384.9°Cat760mmHg
• Flash Point: 186.6°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 3.95E-06mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-chloro-N-cyclohexylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-cyclohexylbenzamide(59507-54-9)
• EPA Substance Registry System: 2-chloro-N-cyclohexylbenzamide(59507-54-9)

Safety Data

• Hazardous Substances Data: 59507-54-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-cyclohexylbenzamide is a chemical compound with the molecular formula C13H16ClNO. It is a white to off-white crystalline powder that is insoluble in water but soluble in organic solvents. 2-chloro-N-cyclohexylbenzamide is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used as a reagent in organic chemical reactions and as a building block for the preparation of other chemical compounds. 2-Chloro-N-cyclohexylbenzamide is known to have potential toxic effects and should be handled with care and according to proper safety protocols.

InChI:InChI=1/C13H16ClNO/c14-12-9-5-4-8-11(12)13(16)15-10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2,(H,15,16)

Upstream product

• 108-91-8 cyclohexylamine 
• 118-91-2 ortho-chlorobenzoic acid 
• 13144-62-2 2-(cyclohexylamino)-2-oxoacetic acid 
• 49619-43-4 2-chlorobenzoic anhydride 

Downstream Products

• 1355223-39-0 2-chloro-N-cyclohexylthiobenzamide 

Relevant articles and documents

An efficient mechanochemical synthesis of amides and dipeptides using 2,4,6-trichloro-1,3,5-triazine and PPh3

A rapid, facile, and efficient mechanochemical synthesis of amides from carboxylic acids has been developed through an in situ acid activation with 2,4,6-trichloro-1,3,5-triazine and a catalytic amount of PPh3. Under room temperature solvent-drop grinding of the reactants in the presence of an inorganic base, a variety of carboxylic acids including aromatic acids, aliphatic acids, and N-protected α-amino acids undergo amidation to afford amides in moderate to excellent yields. The method is also compatible with Fmoc, Cbz, and Boc protecting groups which yields protected optically active dipeptides without detectable racemization.

Pd(ii)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions

A novel Pd-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates has been realized under mild reaction conditions. This method provides an efficient access to N-mono- or N,N-disubstituted benzamides and benzoates.