59514-19-1Relevant academic research and scientific papers
THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
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, (2019/01/17)
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an anim
NOVEL MEANS AND METHODS FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM, METABOLIC AND CARDIAC DISEASES AND AGING
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Page/Page column 47, (2013/10/08)
This invention relates to a compound of formula (la) or (Ila) wherein either (A) R1 is I and R2 is selected from substituted or unsubstituted piperidinyl, preferably N-substituted or unsubstituted piperidin-4-yl; substituted or unsub
CARBAZOLE, CARBOLINE, AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION
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Page/Page column 54; 55, (2008/06/13)
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds and compositions useful in the inhibition of BEGF production, and/or in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Palladium-catalyzed amination and amidation of benzo-fused bromine-containing heterocycles
Sergeev,Artamkina,Velezheva,Fedorova,Beletskaya
, p. 860 - 874 (2007/10/03)
Amination and amidation of bromoindole, 6-bromo-1,2,3,4-tetrahydrocarbazol- 1-one, and 8-bromo-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole derivatives was effected in the presence of palladium complexes. The use of the catalytic system Pd2dba3·CHCl3-2-[di(tert-butyl) phosphino]biphenyl in the amination and of Pd2dba3· CHCl3-Xantphos [or 3,5-(CF3)2Xantphos] in the amidation ensured moderate to high yields of the corresponding products.
