59525-06-3

Basic information

• Product Name: Benzamide, N-[2-(aminothioxomethyl)phenyl]-
• CAS NO: 59525-06-3
• Molecular Formula: C14H12N2OS
• Molecular Weight: 256.328
• Mol File: 59525-06-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[2-(aminothioxomethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[2-(aminothioxomethyl)phenyl]-(59525-06-3)
• EPA Substance Registry System: Benzamide, N-[2-(aminothioxomethyl)phenyl]-(59525-06-3)

Safety Data

• Hazardous Substances Data: 59525-06-3(Hazardous Substances Data)

Upstream product

• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 98-88-4 benzoyl chloride 
• 2454-39-9 2-aminobenzothioamide 

Downstream Products

• 6483-99-4 2-phenyl-3,4-dihydroquinazolin-4-thione 
• 62838-24-8 2-phenyl-4H-benzo[d][1,3]thiazin-4-one 
• 396716-35-1 2-phenyl-4-iminobenzo[d][1,3]thiazine 
• 490016-73-4 bis(2-phenylquinazolin-4-yl) sulphide 
• 6483-99-4 2-phenyl-1⁽³⁾H-quinazoline-4-thione 

Relevant articles and documents

Synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones

Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl-aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautomeric form of selected compounds has been discussed on the basis of their 13C-NMR, IR and Raman spectra. It has been found that in the given medium 1-methyl-quinazoline-4-thiones undergo a replacement of the sulphur substituent by oxygen giving 1-methyl-quinazoline-4-ones. In strong acid media, 2-benzoylaminothiobenzamide is cyclised through its sulphur atom to give 2-phenylbenzo[d-1,3]thiazin-4-one.