5954-50-7

Basic information

• Product Name: Fluorophosphonic acid dimethyl ester
• Synonyms: Fluoridophosphoric acid dimethyl ester;Fluorophosphonic acid dimethyl ester;T-1035;TL-311
• CAS NO: 5954-50-7
• Molecular Formula: C₂H₆FO₃P
• Molecular Weight: 128.05
• Mol File: 5954-50-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 144.21°C (estimate)
• Flash Point: 13.8°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 44.3mmHg at 25°C
• Refractive Index: 1.341
• CAS DataBase Reference: Fluorophosphonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fluorophosphonic acid dimethyl ester(5954-50-7)
• EPA Substance Registry System: Fluorophosphonic acid dimethyl ester(5954-50-7)

Safety Data

• Hazardous Substances Data: 5954-50-7(Hazardous Substances Data)

Usage

Health Hazard

Dimethyl fluorophosphate is a strong acetylcholinesterase inhibitor. It is not used as a military poison. Its toxic actions are similar to those of DFP; the poisoning effects may be slightly greater than those of DFP.LD50 value, skin (mice): 36 mg/kgLC50 value, (mice): 290 mg/m3/10 min.

InChI:InChI=1/C2H6FO3P/c1-5-7(3,4)6-2/h1-2H3

Upstream product

• 60190-80-9 dimethyl (1-diazo-2-oxo-2-phenylethyl)phosphonate 
• 950-35-6 methyl paraoxon 
• 30295-39-7 O,O-dimethyl-S-trifluoromethyl phosphorthioate 

Downstream Products

• 813-78-5 dimethylphosphoric acid 
• 1718-24-7 Trimethylaniliniumsalz der Monomethyl-monofluor-monophosphorsaeure 

Relevant articles and documents

Fluoride-Mediated Dephosphonylation of α-Diazo-β-carbonyl Phosphonates

The possibility of fluoride-mediated selective dephosphonylation of α-diazo-β-carbonyl phosphonates such as the Ohira-Bestmann reagent has been proposed and executed. The resulting α-diazocarbonyl intermediates undergo a (3 + 2)-cycloaddition at room temperature with conjugated olefins and benzynes. Interestingly, under the current conditions, the resulting cycloaddition products underwent either N-acylation (with excess α-diazo-β-carbonyl phosphonates) or Michael addition (with conjugated olefins).

TRANSFORMATION OF ORGANOPHOSPHORUS S-TRIFLUOROMETHYLTHIOATES RR'P(O)SCF3 INTO FLUORIDES RR'P(O)F. STEREOCHEMICAL ASPECTS OF THIOCARBONYL FLUORIDE EXTRUSION

The stereochemical course of the thermal or by nucleophiles catalyzed extrusion reaction of thiocarbonyl fluoride from two diastereomeric (6) and optically active (10) organophosphorus S-trifluoromethylthioates has been investigated.To explain the observed retention of configuration at phosphorus in fluoridates 7 formed in the thermal reactions, a four center transition state for such reactions has been proposed.The lack of the stereoselectivity in the catalyzed reactions of 6, and the observed racemization of the final product 11 are briefly discussed.