59540-22-6

Usage

Uses

Used in Pharmaceutical Industry:
[4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl]trimethylammonium 4-oxide is used as a drug delivery agent for enhancing the solubility and bioavailability of hydrophobic drugs. Its amphiphilic properties enable it to form stable complexes with drugs, improving their absorption and distribution in the body.
Used in Cosmetic Industry:
In the cosmetic industry, [4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl]trimethylammonium 4-oxide is used as an emulsifying agent for creating stable emulsions of oil and water. Its ability to interact with both hydrophilic and hydrophobic substances makes it an effective ingredient for stabilizing various cosmetic formulations, such as creams, lotions, and serums.
Used in Nanotechnology:
[4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl]trimethylammonium 4-oxide is used as a stabilizing agent in the synthesis of nanoparticles. Its amphiphilic nature allows it to form a protective layer around nanoparticles, preventing their aggregation and improving their stability in various applications, such as drug delivery, imaging, and sensing.
Used in Drug Delivery Systems:
Similar to β-Dipalmitoyllecithin, [4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl]trimethylammonium 4-oxide can be used in the development of thermolabile liposomes with controlled release temperature. Its unique structure and properties make it a promising candidate for designing targeted drug delivery systems that can release their payload at specific temperatures or in response to specific stimuli.

InChI:InChI=1/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(49-50(44,45)48-35-34-41(3,4)5)37-47-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3

Upstream product

• 112-67-4 n-hexadecanoyl chloride 
• 75-50-3 trimethylamine 
• 502-52-3 hexadecanoic acid, 2-hydroxy-1,3-propanediyl ester 
• 1301700-49-1 2-[benzyloxy(2-bromoethoxy)phosphoryloxy]propane-1,3-diyldipalmitate 

Relevant academic research and scientific papers

BODP - A versatile reagent for phospholipid synthesis

Benzyloxydichlorophosphine (BODP) has been found to be a convenient reagent for the synthesis of phospholipids. A series of artificial ether and ester phospholipids have been prepared in good to high yields. Georg Thieme Verlag Stuttgart New York.

1,3-Diacylglycero-2-phosphocholines - Synthesis, aggregation behaviour and properties as inhibitors of phospholipase D

A series of 1,3-diacylglycero-2-phosphocholines (1,3-PCs) with acyl chain lengths of C8-C18 were synthesised by chemical introduction of the phosphocholine moiety into the regioisomerically pure 1,3-diacylglycerols, which were obtained from glycerol and the vinyl esters of fatty acid by means of lipase from Rhizomucor mihei. The 1,3-PCs being regioisomers of the natural glycerophospholipids were studied with respect to their aggregation behaviour in the absence and in the presence of sodium dodecylsulfate (SDS) as well as their properties as substrates and inhibitors of phospholipase D (PLD) from cabbage. While the main structures of the pure 1,3-PCs were micelles (C8), liposomes (C10, C12) or planar bilayers (C14, C16, C18), the addition of SDS resulted in the formation of mixed micelles (C8, C10) and mixed liposomes (C12, C14, C16, C18). None of the 1,3-PCs was found to be hydrolysed by PLD, whereas all of them showed inhibitory properties in the standard assay for PLD. The inhibitory power was strongest with 1,3-didecanoylglycero-2-phosphocholine (IC50=43 μM). Copyright (C) 2000 Elsevier Science Ireland Ltd.

Method of lowering the viscosity of mucus

The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: STR1 wherein one of X, Y, or Z represent: STR2 in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R1 in which R1 represents linear or branched C11-21 alkyl or C11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C1-6 linear or branched alkoxy or cyano.