59545-76-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
3-Hydrazino-5-methyl-4H-1,2,4-triazol-4-ylamine hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new drugs and pesticides with improved efficacy and selectivity.
Used in Antimicrobial Applications:
3-Hydrazino-5-methyl-4H-1,2,4-triazol-4-ylamine hydrochloride is used as an antimicrobial agent in the medical and veterinary fields. Its potential to inhibit the growth of bacteria and fungi makes it a valuable component in the development of new antimicrobial drugs and treatments.
Used in Antiviral Applications:
3-Hydrazino-5-methyl-4H-1,2,4-triazol-4-ylamine hydrochloride is used as an antiviral agent, showing promise in inhibiting the replication of various viruses. Its potential use in antiviral drug development can contribute to the creation of new therapies for viral infections.
Used as a Reagent in Organic Synthesis:
3-Hydrazino-5-methyl-4H-1,2,4-triazol-4-ylamine hydrochloride is used as a reagent in organic synthesis, enabling the formation of various heterocyclic compounds. Its versatility in chemical reactions allows for the synthesis of a wide range of organic compounds with diverse applications.
Used in the Preparation of Heterocyclic Compounds:
3-Hydrazino-5-methyl-4H-1,2,4-triazol-4-ylamine hydrochloride is used as a building block for the preparation of heterocyclic compounds. Its unique structure and reactivity make it an essential component in the synthesis of complex heterocyclic molecules with potential applications in various fields, including pharmaceuticals, materials science, and agrochemistry.

InChI:InChI=1/C3H8N6.ClH/c1-2-7-8-3(6-4)9(2)5;/h4-5H2,1H3,(H,6,8);1H

Upstream product

• 64-19-7 acetic acid 
• 20939-15-5 4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 20939-15-5 3-methyl-4-amino-5-mercapto-1,2,4-triazole 

Relevant academic research and scientific papers

DNA cleavage and antimicrobial studies of 17-membered schiff base macrocyclic triazoles: Synthesis and spectroscopic approach

A novel series of 17-membered complexes [MLCl2] (M = Co2+, Ni2+ and Cu2+) have been synthesized with newly derived biologically active ligands (LI-LIV). These ligands were synthesized by the condensation of 3-subtituted-4-amino-5-hydrazino-1,2,4-triazole with bis(phthalaldehyde)ethylenediamine precursor. The structure of the complexes has been proposed by elemental analyses, IR, EPR, electronic spectral studies, conductivity, magnetic, thermal and electrochemical studies. All the complexes are soluble in DMF and DMSO and are non-electrolytes. All these Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by the Agar and Potato dextrose agar diffusion method. The DNA cleavage study was done by Agarose gel electrophoresis technique.

Acylation-Mediated 'Kinetic Turn-On' of 3-Amino-1,2,4,5-tetrazines

The fast and biocompatible ligation of 1,2,4,5-tetrazines with strained alkenes has found numerous applications in biomedical sciences. The reactivity of a 1,2,4,5-tetrazine can generally be tuned by changing its electronic properties by varying the substituents in the 3- and/or 6-position. An increased reactivity of such bioorthogonal probes upon conjugation or attachment to a target molecule has not previously been described. Such an approach would be beneficial, as it would minimize the impact of residual tetrazine reagents and/or impurities. Herein, we describe such a 'kinetic turn-on' of 1,2,4,5-tetrazines upon conjugation. On the basis of the significant increase in reactivity following N-acylation predicted by quantum chemical calculations, we prepared 3-aminotetrazines and their corresponding acetylated derivatives. An investigation of the reaction kinetics indeed revealed a remarkable increase in reactivity upon acylation.

Synthesis, characterization, and biological activity of some novel Schiff bases and their Co(II) and Ni(II) complexes: A new route for Co3O4 and NiO nanoparticles for photocatalytic degradation of methylene blue dye

Six novel Co(II) and Ni(II)-triazole Schiff base complexes have been successfully synthesized by refluxing the prepared triazole Schiff bases with CoCl2·6H2O or NiCl2·6H2O. The Schiff base ligands were prepared through condensation of 3-R-4-amino-5-hydrazino-1,2,4-triazole with dibenzoylmethane [R[dbnd]H, CH3, and CH2CH3; namely, L1, L2, and L3, respectively]. The prepared Co(II) and Ni(II) complexes have been identified using elemental analysis, FT-IR, UV–Vis, magnetic moment, conductivity, and thermal analysis. On the basis of the conductance results, it was concluded that all the prepared complexes are nonelectrolytes. Interestingly, the prepared Co(II) and Ni(II) complexes were employed as precursors for producing of Co3O4 and NiO nanoparticles, respectively. The produced nanostructures have been identified by XRD, HR-TEM, FT-IR and UV–Vis spectra. The produced nanoparticles revealed good photocatalytic activity for the degradation of methylene blue dye under UV illumination in presence of hydrogen peroxide. The percent of degradation was estimated to be 55.71% in 420.0?min and 90.43% in 360.0?min for Co3O4 and NiO, respectively. Moreover, the synthesized complexes, nano-sized Co3O4, and NiO products have been examined, employing modified Bauer- Kirby method, for antifungal (Candida albicans and Aspergillus flavus) and antibacterial (Staphylococcus aureus and Escherichia coli) activities.